Title :

Recent Progress in Intestinal Toxicity of Microplastics and Nanoplastics: Systematic Review of Preclinical Evidence

Author(s) :

Loison, Suzie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Body-Malapel, Mathilde [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]

Journal title :

Microplastics

Abbreviated title :

Microplastics

Volume number :

3

Pages :

217-233

Publication date :

2024-04-08

ISSN :

2673-8929

English keyword(s) :

microplastic
nanoplastic
intestinal
colon
gut barrier
inflammation
oxidative stress
dysbiosis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The tremendous plastic production and poor post-use management are current and future sources of environmental and human contamination due to their degradation products: microplastics and nanoplastics (MNPLs). Methodological ...
Show more >The tremendous plastic production and poor post-use management are current and future sources of environmental and human contamination due to their degradation products: microplastics and nanoplastics (MNPLs). Methodological developments have allowed MNPLs to be detected in an increasing variety of human foods, as well as in stool and colonic mucosa. It was suggested early that the direct contact between MNPLs and intestinal tissues could represent a potential risk for human health. In order to assess this, over the last 3 years, numerous studies have evaluated the impact of MNPL ingestion on intestinal homeostasis in rodents. This comprehensive review reports the preclinical studies published between January 2021 and January 2024, and analyzes their contributions as well as their shortcomings. It shows that evidence is accumulating of the intestinal toxicity of spherical MNPLs, which lead to pro-inflammatory, pro-oxidative, barrier-disruptive and dysbiotic effects. However, the available literature has addressed only a minor part of the potential health issues of MNPLs. Many parameters contributing to MNPL toxicity need to be better taken into account in future studies. Particular attention should be paid to improve the representativeness of MNPLs, as well as to better consider the susceptibility factors of MNPL toxicity, generated especially by an underlying pathology or pathological imprinting.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2024-09-01T21:00:45Z
2024-09-09T08:22:50Z