Description of an original molecular ...
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Article dans une revue scientifique: Article original
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Title :
Description of an original molecular ordering process into a disordered crystalline form: the atypical low-temperature transformation of the disordered form III of linezolid
Author(s) :
Khalaji, Mehrnaz [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Department of Bioorganic Chemistry Centre of Molecular and Macromolecular Studies Polish Academy of Sciences
Dudek, Marta Katarzyna [Auteur]
Department of Bioorganic Chemistry Centre of Molecular and Macromolecular Studies Polish Academy of Sciences
Paccou, Laurent [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Danede, Florence [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Guinet, Yannick [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Hedoux, Alain [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Department of Bioorganic Chemistry Centre of Molecular and Macromolecular Studies Polish Academy of Sciences
Dudek, Marta Katarzyna [Auteur]
Department of Bioorganic Chemistry Centre of Molecular and Macromolecular Studies Polish Academy of Sciences
Paccou, Laurent [Auteur]

Unité Matériaux et Transformations - UMR 8207 [UMET]
Danede, Florence [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Guinet, Yannick [Auteur]

Unité Matériaux et Transformations - UMR 8207 [UMET]
Hedoux, Alain [Auteur]

Unité Matériaux et Transformations - UMR 8207 [UMET]
Journal title :
Physical Chemistry Chemical Physics
Volume number :
26
Pages :
20709-20716
Publisher :
Royal Society of Chemistry (RSC)
Publication date :
2024-07-10
ISSN :
1463-9076
HAL domain(s) :
Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]
English abstract : [en]
Form III of linezolid was prepared by heating the commercial form above 150 °C and subsequently analyzed upon cooling down to −160 °C, by low- and high-frequency Raman spectroscopy, differential scanning calorimetry and ...
Show more >Form III of linezolid was prepared by heating the commercial form above 150 °C and subsequently analyzed upon cooling down to −160 °C, by low- and high-frequency Raman spectroscopy, differential scanning calorimetry and powder X-ray diffraction (PXRD). It was observed that form III was preserved down to 0 °C. At lower temperatures a soft mode was clearly detected by low-frequency Raman spectroscopy associated with the detection of additional Raman bands distinctive of additional intermolecular H-bond interactions. Raman spectroscopy investigations performed in a wide frequency range revealed a continuous transformation characterized by both displacive and order–disorder signatures. By contrast, PXRD highlighted the absence of symmetry breaking, Bragg peaks being still indexed in the same unit cell from room temperature down to −160 °C. Additionally, a significant broadening of Bragg peaks was observed with decreasing temperature interpreted as being a consequence of a distribution of frozen molecular conformations.Show less >
Show more >Form III of linezolid was prepared by heating the commercial form above 150 °C and subsequently analyzed upon cooling down to −160 °C, by low- and high-frequency Raman spectroscopy, differential scanning calorimetry and powder X-ray diffraction (PXRD). It was observed that form III was preserved down to 0 °C. At lower temperatures a soft mode was clearly detected by low-frequency Raman spectroscopy associated with the detection of additional Raman bands distinctive of additional intermolecular H-bond interactions. Raman spectroscopy investigations performed in a wide frequency range revealed a continuous transformation characterized by both displacive and order–disorder signatures. By contrast, PXRD highlighted the absence of symmetry breaking, Bragg peaks being still indexed in the same unit cell from room temperature down to −160 °C. Additionally, a significant broadening of Bragg peaks was observed with decreasing temperature interpreted as being a consequence of a distribution of frozen molecular conformations.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
INRAE
ENSCL
CNRS
INRAE
ENSCL
Collections :
Research team(s) :
Matériaux Moléculaires et Thérapeutiques
Submission date :
2024-09-02T13:21:28Z
2024-09-04T06:49:59Z
2024-09-04T06:49:59Z
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