Virucidal activity of porphyrin-based ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Virucidal activity of porphyrin-based metal-organic frameworks against highly pathogenic coronaviruses and hepatitis C virus
Author(s) :
Plastiras, Orfeas-Evangelos [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Bouquet, Peggy [Auteur]
Institut Pasteur de Lille
Raczkiewicz, Imelda [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Belouzard, Sandrine [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Martin De Fourchambault, Esther [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Dhainaut, Jérémy [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Dacquin, Jean-Philippe [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Goffard, Anne [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Volkringer, Christophe [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Bouquet, Peggy [Auteur]
Institut Pasteur de Lille
Raczkiewicz, Imelda [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Belouzard, Sandrine [Auteur]

Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Martin De Fourchambault, Esther [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Dhainaut, Jérémy [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Dacquin, Jean-Philippe [Auteur]

Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Goffard, Anne [Auteur]

Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Volkringer, Christophe [Auteur]

Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Journal title :
Materials Today Bio
Abbreviated title :
Mater Today Bio
Volume number :
28
Pages :
101165
Publisher :
Elsevier
Publication date :
2024-08-02
ISSN :
2590-0064
English keyword(s) :
Metal-organic framework
Antiviral
SARS-CoV-2
HCoV-229E
Hepatitis C virus
Antiviral
SARS-CoV-2
HCoV-229E
Hepatitis C virus
HAL domain(s) :
Chimie/Catalyse
Chimie/Chimie inorganique
Chimie/Chimie inorganique
English abstract : [en]
The antiviral effect of four porphyrin-based Metal-Organic Frameworks (PMOFs) with Al and Zr, namely Al-TCPP, PCN-222, PCN-223 and PCN-224 was assessed for the first time against HCoV-229E, two highly pathogenic coronaviruses ...
Show more >The antiviral effect of four porphyrin-based Metal-Organic Frameworks (PMOFs) with Al and Zr, namely Al-TCPP, PCN-222, PCN-223 and PCN-224 was assessed for the first time against HCoV-229E, two highly pathogenic coronaviruses (SARS-CoV-2 and MERS-CoV) and hepatitis C virus (HCV). Infection tests in vitro were done under dark or light exposure for different contact times, and it was found that 15 min of light exposure were enough to give antiviral properties to the materials, therefore inactivating HCoV-229E by 99.98 % and 99.96 % for Al-TCPP and PCN-222. Al-TCPP diminished the viral titer of SARS-CoV-2 greater than PCN-222 in the same duration of light exposure, having an effect of 99.95 % and 93.48 % respectively. Next, Al-TCPP was chosen as the best candidate possessing antiviral properties and was tested against MERS-CoV and HCV, showcasing a reduction of infectivity of 99.28 % and 98.15 % respectively for each virus. The mechanism of the antiviral activity of the four PMOFs was found to be the production of singlet oxygen 1O2 from the porphyrin ligand TCPP when exposed to visible light, by using sodium azide (NaN3) as a scavenger, that can later attack the phospholipids on the envelope of the viruses, thus preventing their entry into the cells.Show less >
Show more >The antiviral effect of four porphyrin-based Metal-Organic Frameworks (PMOFs) with Al and Zr, namely Al-TCPP, PCN-222, PCN-223 and PCN-224 was assessed for the first time against HCoV-229E, two highly pathogenic coronaviruses (SARS-CoV-2 and MERS-CoV) and hepatitis C virus (HCV). Infection tests in vitro were done under dark or light exposure for different contact times, and it was found that 15 min of light exposure were enough to give antiviral properties to the materials, therefore inactivating HCoV-229E by 99.98 % and 99.96 % for Al-TCPP and PCN-222. Al-TCPP diminished the viral titer of SARS-CoV-2 greater than PCN-222 in the same duration of light exposure, having an effect of 99.95 % and 93.48 % respectively. Next, Al-TCPP was chosen as the best candidate possessing antiviral properties and was tested against MERS-CoV and HCV, showcasing a reduction of infectivity of 99.28 % and 98.15 % respectively for each virus. The mechanism of the antiviral activity of the four PMOFs was found to be the production of singlet oxygen 1O2 from the porphyrin ligand TCPP when exposed to visible light, by using sodium azide (NaN3) as a scavenger, that can later attack the phospholipids on the envelope of the viruses, thus preventing their entry into the cells.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
Centrale Lille
ENSCL
Univ. Artois
CNRS
Centrale Lille
ENSCL
Univ. Artois
Collections :
Research team(s) :
Matériaux pour la catalyse (MATCAT)
Matériaux hybrides (MATHYB)
Virologie Moléculaire et Cellulaire
Matériaux hybrides (MATHYB)
Virologie Moléculaire et Cellulaire
Submission date :
2024-09-05T21:04:16Z
2024-09-09T14:52:21Z
2024-09-09T14:52:21Z
Files
- 1-s2.0-S2590006424002266-main.pdf
- Version éditeur
- Open access
- Access the document
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 3.0 United States