Interactions Between Eosinophils and IL5Rα+ ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Title :
Interactions Between Eosinophils and IL5Rα+ Mast Cells in Non-Advanced Systemic Mastocytosis.
Author(s) :
Lefevre, Guillaume [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Gibier, Jean-Baptiste [Auteur]
Université de Lille
Institut de Pathologie [CHU Lille]
Bongiovanni, Antonino [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Lhermitte, Ludovic [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Rossignol, Julien [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Anglo, Emilie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Dendooven, Arnaud [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Dubois, Romain [Auteur]
Université de Lille
Institut de Pathologie [CHU Lille]
Terriou, Louis [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Launay, David [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Barete, Stéphane [Auteur]
Sorbonne Université [SU]
Esnault, Stéphane [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Frenzel, Laurent [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Gourguechon, Clément [Auteur]
CHU Amiens-Picardie
Ballul, Thomas [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Dezoteux, Frederic [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Staumont, Delphine [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Copin, Marie-Christine [Auteur]
Université d'Angers [UA]
Rignault-Bricard, Rachel [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Maciel, Thiago Trovati [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Damaj, Gandhi [Auteur]
Université de Caen Normandie [UNICAEN]
Tardivel, Meryem [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Crinquette-Verhasselt, Marie [Auteur]
Institut de Pathologie [CHU Lille]
Université de Lille
Dubreuil, Patrice [Auteur]
Aix Marseille Université [AMU]
Maouche-Chrétien, Leila [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Bruneau, Julie [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Duployez, Nicolas [Auteur]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Behal, Helene [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Molina, Thierry Jo [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Aix Marseille Université [AMU]
Hermine, Olivier [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]

Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Gibier, Jean-Baptiste [Auteur]
Université de Lille
Institut de Pathologie [CHU Lille]
Bongiovanni, Antonino [Auteur]
Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Lhermitte, Ludovic [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Rossignol, Julien [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Anglo, Emilie [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Dendooven, Arnaud [Auteur]

Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Dubois, Romain [Auteur]
Université de Lille
Institut de Pathologie [CHU Lille]
Terriou, Louis [Auteur]

Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Launay, David [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Barete, Stéphane [Auteur]
Sorbonne Université [SU]
Esnault, Stéphane [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Frenzel, Laurent [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Gourguechon, Clément [Auteur]
CHU Amiens-Picardie
Ballul, Thomas [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Dezoteux, Frederic [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Staumont, Delphine [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Copin, Marie-Christine [Auteur]

Université d'Angers [UA]
Rignault-Bricard, Rachel [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Maciel, Thiago Trovati [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Damaj, Gandhi [Auteur]
Université de Caen Normandie [UNICAEN]
Tardivel, Meryem [Auteur]

Plateformes Lilloises en Biologie et Santé - UAR 2014 - US 41 [PLBS]
Crinquette-Verhasselt, Marie [Auteur]
Institut de Pathologie [CHU Lille]
Université de Lille
Dubreuil, Patrice [Auteur]
Aix Marseille Université [AMU]
Maouche-Chrétien, Leila [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Bruneau, Julie [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Duployez, Nicolas [Auteur]

Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]
Behal, Helene [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Molina, Thierry Jo [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Aix Marseille Université [AMU]
Hermine, Olivier [Auteur]
Imagine - Institut des maladies génétiques (IHU) [Imagine - U1163]
Journal title :
Journal of Allergy and Clinical Immunology
Publisher :
Elsevier
Publication date :
2024-08-14
ISSN :
0091-6749
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BackgroundBidirectional interactions between eosinophils and mast cells (MCs) have been reported in various allergic diseases. Bone marrow (BM) eosinophilia, and to a lesser extent blood eosinophilia, is common in systemic ...
Show more >BackgroundBidirectional interactions between eosinophils and mast cells (MCs) have been reported in various allergic diseases. Bone marrow (BM) eosinophilia, and to a lesser extent blood eosinophilia, is common in systemic mastocytosis (SM), but its significance remains unknown.ObjectiveTo describe blood and BM eosinophil characteristics in SM.MethodsA large collection of BM biopsies was analyzed using immunohistochemical staining and whole-slide imaging. Eosinophil and extracellular granules were detected by eosinophil peroxidase (EPX) staining, and MCs by KIT staining. Complementary analyses were conducted using flow cytometry and immunofluorescence.ResultsEosinophil infiltrates and large areas of eosinophil degranulation were observed within or around BM MC infiltrates in SM. EPX staining surface, highlighting intact eosinophils and eosinophil degranulation, was higher in non-advanced-SM (n=37 BM biopsies) compared to both controls (n=8, p=0.0003) and to advanced SM (n=24, p=0.014). In non-advanced SM, positive correlations were observed between serum tryptase levels and percentages of eosinophil counts in BM aspirations (Spearman r coefficient r=0.38, p=0.038), eosinophils count in BM biopsies (r=0.45, p=0.007), EPX staining (r=0.37, p=0.035) and eosinophil degranulation (r=0.39, p=0.023). Eosinophil counts in BM biopsies also correlated with MC counts (r=0.47, p=0.006) and KIT staining surface (r=0.49, p=0.003). BM MCs expressed interleukin-5 receptor and other usual eosinophil cytokine/chemokine receptors, and blood eosinophils display several increased surface markers compared to controls, suggesting an activated state.ConclusionOur data suggest a possible crosstalk between MCs and eosinophils, supporting MC tryptase release and MC activation-related symptoms. This suggests a rationale for targeting eosinophils in non-advanced-SM not fully controlled by other therapies.Show less >
Show more >BackgroundBidirectional interactions between eosinophils and mast cells (MCs) have been reported in various allergic diseases. Bone marrow (BM) eosinophilia, and to a lesser extent blood eosinophilia, is common in systemic mastocytosis (SM), but its significance remains unknown.ObjectiveTo describe blood and BM eosinophil characteristics in SM.MethodsA large collection of BM biopsies was analyzed using immunohistochemical staining and whole-slide imaging. Eosinophil and extracellular granules were detected by eosinophil peroxidase (EPX) staining, and MCs by KIT staining. Complementary analyses were conducted using flow cytometry and immunofluorescence.ResultsEosinophil infiltrates and large areas of eosinophil degranulation were observed within or around BM MC infiltrates in SM. EPX staining surface, highlighting intact eosinophils and eosinophil degranulation, was higher in non-advanced-SM (n=37 BM biopsies) compared to both controls (n=8, p=0.0003) and to advanced SM (n=24, p=0.014). In non-advanced SM, positive correlations were observed between serum tryptase levels and percentages of eosinophil counts in BM aspirations (Spearman r coefficient r=0.38, p=0.038), eosinophils count in BM biopsies (r=0.45, p=0.007), EPX staining (r=0.37, p=0.035) and eosinophil degranulation (r=0.39, p=0.023). Eosinophil counts in BM biopsies also correlated with MC counts (r=0.47, p=0.006) and KIT staining surface (r=0.49, p=0.003). BM MCs expressed interleukin-5 receptor and other usual eosinophil cytokine/chemokine receptors, and blood eosinophils display several increased surface markers compared to controls, suggesting an activated state.ConclusionOur data suggest a possible crosstalk between MCs and eosinophils, supporting MC tryptase release and MC activation-related symptoms. This suggests a rationale for targeting eosinophils in non-advanced-SM not fully controlled by other therapies.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
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