Titre :

Functional architecture of executive processes: Evidence from verbal fluency and lesion mapping in stroke patients

Auteur(s) :

Godefroy, Olivier [Auteur]
GRECogVASC study group
Aarabi, Ardalan [Auteur]
GRECogVASC study group
Dorchies, Flore [Auteur]
GRECogVASC study group
Barbay, Mélanie [Auteur]
GRECogVASC study group
Andriuta, Daniela [Auteur]
GRECogVASC study group
Diouf, Momar [Auteur]
GRECogVASC study group
Thiebaut de Schotten, Michel [Auteur]
GRECogVASC study group
Kassir, Rania [Auteur]
GRECogVASC study group
Tasseel-Ponche, Sophie [Auteur]
GRECogVASC study group
Roussel, Martine [Auteur]
GRECogVASC study group
Barbay, Mélanie [Auteur]
Canaple, Sandrine [Auteur]
Lamy, Chantal [Auteur]
Leclercq, Claire [Auteur]
Courselle-Arnoux, Audrey [Auteur]
Despretz-Wannepain, Sandrine [Auteur]
Despretz, Pascal [Auteur]
Université de Lille
Berrissoul, Hassan [Auteur]
Picard, Carl [Auteur]
Loas, Gwénolé [Auteur]
Deramond, Hervé [Auteur]
Taillia, Hervé [Auteur]
Ardisson, Anne-Emmanuelle [Auteur]
Nédélec-Ciceri, Claudine [Auteur]
Bonnin, Camille [Auteur]
Thomas-Anterion, Catherine [Auteur]
Vincent-Grangette, Francoise [Auteur]
Varvat, Jérome [Auteur]
Quaglino, Véronique [Auteur]
Beaunieux, Hélène [Auteur]
Moroni, Christine [Auteur]
Psychologie : Interactions, Temps, Emotions, Cognition (PSITEC) - ULR 4072 [PSITEC]
GRECogVASC study group
Université de Lille, Sciences Humaines et Sociales
Martens-Chazelles, Audrey [Auteur]
Batier-Monperrus, Stéphanie [Auteur]
Monteleone, Cécile [Auteur]
Costantino, Véronique [Auteur]
Theunssens, Eric [Auteur]
Despretz, Pascal [Auteur]

Titre de la revue :

Cortex

Nom court de la revue :

Cortex

Numéro :

164

Pagination :

129-143

Éditeur :

Elsevier BV

Date de publication :

2023-07

ISSN :

0010-9452

Résumé en anglais : [en]

The functional organization and related anatomy of executive functions are still largely unknown and were examined in the present study using a verbal fluency task. The objective of this study was to determine the cognitive ...
Lire la suite >The functional organization and related anatomy of executive functions are still largely unknown and were examined in the present study using a verbal fluency task. The objective of this study was to determine the cognitive architecture of a fluency task and related voxelwise anatomy in the GRECogVASC cohort and fMRI based meta-analytical data. First, we proposed a model of verbal fluency in which two control processes, lexico-semantic strategic search process and attention process, interact with semantic and lexico-phonological output processes. This model was assessed by testing 404 patients and 775 controls for semantic and letter fluency, naming, and processing speed (Trail Making test part A). Regression (R2 = .276 and .3, P = .0001, both) and structural equation modeling (CFI: .88, RMSEA: .2, SRMR: .1) analyses supported this model. Second, voxelwise lesion-symptom mapping and disconnectome analyses demonstrated fluency to be associated with left lesions of the pars opercularis, lenticular nucleus, insula, temporopolar region, and a large number of tracts. In addition, a single dissociation showed specific association of letter fluency with the pars triangularis of F3. Disconnectome mapping showed the additional role of disconnection of left frontal gyri and thalamus. By contrast, these analyses did not identify voxels specifically associated with lexico-phonological search processes. Third, meta-analytic fMRI data (based on 72 studies) strikingly matched all structures identified by the lesion approach. These results support our modeling of the functional architecture of verbal fluency based on two control processes (strategic search and attention) operating on semantic and lexico-phonologic output processes. Multivariate analysis supports the prominent role of the temporopolar area (BA 38) in semantic fluency and the F3 triangularis area (BA 45) in letter fluency. Finally, the lack of voxels specifically dedicated to strategic search processes could be due to a distributed organization of executive functions warranting further studies.Lire moins >

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille

Collections :

• Psychologie : Interactions, Temps, Émotions, Cognition (PSITEC) - ULR 4072

Équipe(s) de recherche :

Neuropsychologie & Audition

Date de dépôt :

2024-09-28T10:23:08Z
2024-10-09T06:11:30Z