Airway Response to Methacholine following ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Airway Response to Methacholine following Eucapnic Voluntary Hyperpnea in Athletes
Auteur(s) :
Bougault, Valerie [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Blouin, Evelyne [Auteur]
Faculté de médecine de l'Université Laval [Québec] [ULaval]
Turmel, Julie [Auteur]
Faculté de médecine de l'Université Laval [Québec] [ULaval]
Boulet, Louis-Philippe [Auteur]
Activité Physique, Muscle, Santé - URePSSSS [APMS]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Blouin, Evelyne [Auteur]
Faculté de médecine de l'Université Laval [Québec] [ULaval]
Turmel, Julie [Auteur]
Faculté de médecine de l'Université Laval [Québec] [ULaval]
Boulet, Louis-Philippe [Auteur]
Activité Physique, Muscle, Santé - URePSSSS [APMS]
Titre de la revue :
PLoS One
Nom court de la revue :
PLoS One
Numéro :
10
Date de publication :
2015-03-19
ISSN :
1932-6203
Mot(s)-clé(s) en anglais :
Mesh:Bronchial Hyperreactivity/diagnosis
Mesh:Young Adult
Mesh:Respiratory System/physiopathology
Mesh:Respiratory System/drug effects*
Mesh:Methacholine Chloride/pharmacology*
Mesh:Male
Mesh:Humans
Mesh:Forced Expiratory Volume/drug effects
Mesh:Female
Mesh:Exercise
Mesh:Bronchoconstriction/drug effects
Mesh:Bronchial Provocation Tests*
Mesh:Athletes*
Mesh:Young Adult
Mesh:Respiratory System/physiopathology
Mesh:Respiratory System/drug effects*
Mesh:Methacholine Chloride/pharmacology*
Mesh:Male
Mesh:Humans
Mesh:Forced Expiratory Volume/drug effects
Mesh:Female
Mesh:Exercise
Mesh:Bronchoconstriction/drug effects
Mesh:Bronchial Provocation Tests*
Mesh:Athletes*
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
OBJECTIVE: To evaluate the changes in airway responsiveness to methacholine inhalation test (MIT) when performed after an eucapnic voluntary hyperpnea challenge (EVH) in athletes.
METHODS: Two MIT preceded (visit 1) or ...
Lire la suite >OBJECTIVE: To evaluate the changes in airway responsiveness to methacholine inhalation test (MIT) when performed after an eucapnic voluntary hyperpnea challenge (EVH) in athletes. METHODS: Two MIT preceded (visit 1) or not (visit 2) by an EVH, were performed in 28 athletes and 24 non-athletes. Twelve athletes and 13 non-athletes had airway hyperresponsiveness (AHR) to methacholine, and 11 athletes and 11 non-athletes had AHR to EVH (EVH+). RESULTS: The MIT PC20 post-EVH was significantly lower compared to baseline MIT PC20 by 1.3±0.7 doubling-concentrations in EVH+ athletes only (p<0.0001). No significant change was observed in EVH- athletes and EVH+/EVH- non-athletes. A significant correlation between the change in MIT PC20 post-EVH and EVH+/EVH- status and athlete/nonathlete status was found (Adjusted R2=0.26 and p<0.001). Three (11%) athletes and one (4%) non-athlete had a change in the diagnosis of AHR when MIT was performed consecutively to EVH. CONCLUSIONS: The responsiveness to methacholine was increased by a previous indirect challenge in EVH+ athletes only. The mechanisms for such increase remain to be determined. MIT and EVH should ideally be performed on separate occasions as there is a small but possible risk to obtain a false-positive response to methacholine when performed immediately after the EVH. BACKGROUND: ClinicalTrials.gov NCT00686491.Lire moins >
Lire la suite >OBJECTIVE: To evaluate the changes in airway responsiveness to methacholine inhalation test (MIT) when performed after an eucapnic voluntary hyperpnea challenge (EVH) in athletes. METHODS: Two MIT preceded (visit 1) or not (visit 2) by an EVH, were performed in 28 athletes and 24 non-athletes. Twelve athletes and 13 non-athletes had airway hyperresponsiveness (AHR) to methacholine, and 11 athletes and 11 non-athletes had AHR to EVH (EVH+). RESULTS: The MIT PC20 post-EVH was significantly lower compared to baseline MIT PC20 by 1.3±0.7 doubling-concentrations in EVH+ athletes only (p<0.0001). No significant change was observed in EVH- athletes and EVH+/EVH- non-athletes. A significant correlation between the change in MIT PC20 post-EVH and EVH+/EVH- status and athlete/nonathlete status was found (Adjusted R2=0.26 and p<0.001). Three (11%) athletes and one (4%) non-athlete had a change in the diagnosis of AHR when MIT was performed consecutively to EVH. CONCLUSIONS: The responsiveness to methacholine was increased by a previous indirect challenge in EVH+ athletes only. The mechanisms for such increase remain to be determined. MIT and EVH should ideally be performed on separate occasions as there is a small but possible risk to obtain a false-positive response to methacholine when performed immediately after the EVH. BACKGROUND: ClinicalTrials.gov NCT00686491.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Équipe(s) de recherche :
Activité Physique, Muscle, Santé (APMS)
Date de dépôt :
2019-09-24T07:26:57Z
2020-03-26T09:15:47Z
2020-03-26T09:15:47Z
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