Titre :

Survival and Prognostic Factors after Adrenalectomy for Secondary Malignancy: A Combined Analysis of a French University Center Registry (Eurocrine ®) of 307 Patients and a French Nationwide Study of 2,515 Patients

Auteur(s) :

Remond, Agathe [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Marciniak, Camille [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Lenne, Xavier [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Chouraki, Vincent [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Gobert, Mathilde [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Baud, Gregory [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Maillard, Laure [Auteur]
Hospices Civils de Lyon [HCL]
Bouriez, Damien [Auteur]
Université de Bordeaux [UB]
Liekens, Ellen [Auteur]
Assistance Publique - Hôpitaux de Marseille [APHM]
Donatini, Gianluca [Auteur]
Université de Poitiers = University of Poitiers [UP]
Ischémie reperfusion, métabolisme et inflammation stérile en transplantation [U 1313] [IRMETIST [Poitiers]]
Nominé-Criqui, Claire [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Ravenet, Ambroise [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Santucci, Nicolas [Auteur]
CHU Dijon
Kuczma, Paulina [Auteur]
Sorbonne Université [SU]
Bouviez, Nicolas [Auteur]
Centre Hospitalier Régional Universitaire de Besançon [CHRU Besançon]
Tresallet, Christophe [Auteur]
Sorbonne Université [SU]
Mirallié, Eric [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Deguelte, Sophie [Auteur]
Hôpital universitaire Robert Debré [Reims] [CHU Reims]
Brunaud, Laurent [Auteur]
Centre Hospitalier Régional Universitaire de Nancy [CHRU Nancy]
Guerin, Carole [Auteur]
Hôpital de la Conception [CHU - APHM] [LA CONCEPTION]
Gronnier, Caroline [Auteur]
Université de Bordeaux [UB]
Lifante, Jean-Christophe [Auteur]
Hospices Civils de Lyon [HCL]
Bruandet, Amelie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Theis, Didier [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Cortot, Alexis [Auteur]
Hôpital Albert Calmette
Scherpereel, Arnaud [Auteur]
Thérapies Assistées par Lasers et Immunothérapies pour l'Oncologie - U 1189 [OncoThAI]
Hamroun, Aghiles [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Pattou, Francois [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]
Caiazzo, Robert [Auteur]
Recherche translationnelle sur le diabète - U 1190 [RTD]

Titre de la revue :

Annals of Surgery

Pagination :

825-834

Éditeur :

Lippincott, Williams & Wilkins

Date de publication :

2024-11-01

ISSN :

0003-4932

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

<b>Objective:</b> To provide a nationwide description of postoperative outcomes and analysis of prognostic factors following adrenalectomy for metastases.<br /><b>Background:</b> Adrenal glands are a common site of metastases ...
Lire la suite ><b>Objective:</b> To provide a nationwide description of postoperative outcomes and analysis of prognostic factors following adrenalectomy for metastases.<br /><b>Background:</b> Adrenal glands are a common site of metastases in many malignancies. Diagnosis of adrenal metastases is on the rise, leading to an increasing number of patient candidates for surgery without consensual management.<br /><b>Methods:</b> We conducted a population-based study between January 2012 and December 2022 using the French National Health Data System (SNDS) and the Eurocrine registry (NCT03410394). The first database exhaustively covers all procedures carried out in France, while the second provides more clinical information on procedures and tumor characteristics, based on the experience of 11 specialized centers.<br /><b>Results:</b> From the SNDS, we extracted 2515 patients who underwent adrenalectomy for secondary malignancy and 307 from the Eurocrine database. The most common primary malignancies were lung cancer (n=1203, 47.8%) and renal cancer (n=555, 22.1%). One-year survival was 84.3% (n=2120). Thirty-day mortality and morbidity rates were, respectively, 1.3% (n=32) and 29.9% (n=753, including planned intensive care unit - stays). Radiotherapy within the year before adrenalectomy was significantly associated with higher 30-day major complication rates (P=0.039). In the Eurocrine database, the proportion of laparoscopic procedures reached 85.3% without impairing resection completeness (R0: 92.9%). Factors associated with poor overall survival were the presence of extra-adrenal metastases (hazard ratio =0.64; P=0.031) and incomplete resection (≥R1; hazard ratio=0.41; P=0.015).<br /><b>Conclusions:</b> The number of patients who can receive local treatment for adrenal metastases is rising, and adrenalectomy is more often minimally invasive and has a low morbidity rate. Subsequent research should evaluate which patients would benefit from adrenal surgery.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Thérapies Lasers Assistées par l'Image pour l'Oncologie (ONCO-THAI) - U1189

Source :

Harvested from HAL