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Reference Ranges for Shape Indices of the ...
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Document type :
Article dans une revue scientifique
DOI :
10.1002/ppul.23112
PMID :
25367592
Permalink :
http://hdl.handle.net/20.500.12210/11859
Title :
Reference Ranges for Shape Indices of the Flow-Volume Loop of Healthy Children
Author(s) :
Nève, Véronique [Auteur]
Edme, Jean-Louis [Auteur]
IMPact de l’Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
IMPact de l’Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Baquet, Georges [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - EA 7369
Matran, Regis [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - EA 4483
Journal title :
Pediatric pulmonology
Abbreviated title :
Pediatr. Pulmonol.
Volume number :
50
Pages :
1017-1024
Publication date :
2015-10-01
ISSN :
8755-6863
English keyword(s) :
Spirometry refference values
Pediatric lung function testing
preschool and school lung function
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
BACKGROUND: The concavity of the descending limb of the maximum expiratory flow-volume loop (MEFVL) is the earliest change associated with airflow obstruction in small airways (ATS/ERS Task Force). The shape of the MEFVL ...
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BACKGROUND: The concavity of the descending limb of the maximum expiratory flow-volume loop (MEFVL) is the earliest change associated with airflow obstruction in small airways (ATS/ERS Task Force). The shape of the MEFVL changes with age but there are no reference values for shape indices for preschool and school children. OBJECTIVE: To define pediatric reference values for spirometric data and 3 shape indices of MEFVL: 2 geometric indices: the β angle i.e., the angle between the first ½ part and the 2nd part of the MEFVL and the forced expiratory flow after 50% of the forced vital capacity (FVC) has been exhaled/peak expiratory flow (FEF50 /PEF) ratio; and a ratio that describes relative growth between airway and lung parenchyma, the forced expiratory flow between 25 and 75% of FVC/FVC ratio (FEF25-75 /FVC ratio). METHODS: Data were obtained from 446 Caucasian children (2.5 to 15-year-old). The lambda, mu, sigma method was applied. RESULTS: References for spirometric parameters and 3 shape indices. The geometric indices decreased with age from 3 years of age (mean β angle was 215° and FEF50 /PEF ratio was 0.82) until 8 years of age (mean β angle was 191° and FEF50 /PEF ratio was 0.60) and then remained constant. The FEF25-75 /FVC ratio also decreased with age. Sex was a significant determinant for FEF25-75 /FVC ratio predicted values. CONCLUSIONS: This study provides standard reference equations for indices of mid-expiratory flows in children and we suggest using the FEF50 /PEF index.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
Univ. Littoral Côte d’Opale
Univ. Artois
Université de Lille
Institut Pasteur de Lille
Collections :
  • IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
  • Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Research team(s) :
Activité Physique, Muscle, Santé (APMS)
Submission date :
2019-09-24T07:27:12Z
Université de Lille

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