Title :

Disparity landscapes of viral-induced structural variations in HCC: Mechanistic characterization and functional implications

Author(s) :

Lyu, Xueying [Auteur]
Sze, Karen Man-Fong [Auteur]
Lee, Joyce Man-Fong [Auteur]
Husain, Abdullah [Auteur]
Tian, Lu [Auteur]
Imbeaud, Sandrine [Auteur]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Zucman-Rossi, Jessica [Auteur]
Université Paris Cité [UPCité]
Centre de Recherche des Cordeliers [CRC (UMR_S_1138 / U1138)]
Hôpital Européen Georges Pompidou [APHP] [HEGP]
Cancer Research and Personalized Medicine - CARPEM [Paris] [SIRIC CARPEM]
Equipe Labellisée
Ng, Irene Oi-Lin [Auteur]
Ho, Daniel Wai-Hung [Auteur]

Journal title :

Hepatology

Publisher :

Wiley-Blackwell

Publication date :

2024-09-13

ISSN :

0270-9139

HAL domain(s) :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Hépatologie et Gastroentérologie
Sciences du Vivant [q-bio]
Sciences du Vivant [q-bio]/Cancer
Sciences du Vivant [q-bio]/Génétique/Génétique humaine

English abstract : [en]

Background and Aims: HCC is the most common type of primary liver cancer and is a common malignancy worldwide. About half of all new liver cancers worldwide each year occur in China, including Hong Kong, due to a high ...
Show more >Background and Aims: HCC is the most common type of primary liver cancer and is a common malignancy worldwide. About half of all new liver cancers worldwide each year occur in China, including Hong Kong, due to a high prevalence of HBV infection. HBV DNA integrates into the human genome, disrupting the endogenous tumor suppressors/regulatory genes or enhancing the activity of proto-oncogenes. It would be useful to examine the different NGS-based databases to provide a more unbiased and comprehensive survey of HBV integration. Approach and Results: We aimed to take advantage of publicly available data sets of different regional cohorts to determine the disparity landscapes of integration events among sample cohorts, tissue types, chromosomal positions, individual host, and viral genes, as well as genic locations. By comparing HCC tumors with non tumorous livers, the landscape of HBV integration was delineated in gene-independent and gene-dependent manners. Moreover, we performed mechanistic investigations on how HBV-TERT integration led to TERT activation and derived a score to predict patients’ prognostication according to their clonal disparity landscape of HBV integration. Conclusions: Our study uncovered the different levels of clonal enrichment of HBV integration and identified mechanistic insights and prognostic biomarkers. This strengthens our understanding of HBV-associated hepatocarcinogenesis.Show less >

Language :

Anglais

Popular science :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL