Titre :

Neuronal tau species transfer to astrocytes and induce their loss according to tau aggregation state.

Auteur(s) :

Maté De Gérando, Anastasie [Auteur]
D'orange, Marie [Auteur]
Augustin, Emma [Auteur]
Joséphine, Charlène [Auteur]
Aurégan, Gwénaelle [Auteur]
Gaudin-Guérif, Mylène [Auteur]
Guillermier, Martine [Auteur]
Hérard, Anne-Sophie [Auteur]
Stimmer, Lev [Auteur]
Petit, Fanny [Auteur]
Gipchtein, Pauline [Auteur]
Jan, Caroline [Auteur]
Escartin, Carole [Auteur]
Selingue, Erwan [Auteur]
Carvalho, Kévin [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
Blum, David [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Brouillet, Emmanuel [Auteur]
Hantraye, Philippe [Auteur]
Gaillard, Marie-Claude [Auteur]
Bonvento, Gilles [Auteur]
Bemelmans, Alexis-Pierre [Auteur]
Cambon, Karine [Auteur]

Titre de la revue :

Brain

Nom court de la revue :

Brain

Numéro :

144

Pagination :

1167–1182

Date de publication :

2021-04

ISSN :

1460-2156

Mot(s)-clé(s) en anglais :

tau
glia
gene-transfer
design-based stereology
Thy-Tau22

Résumé en anglais : [en]

Deposits of different abnormal forms of tau in neurons and astrocytes represent key anatomo-pathological features of tauopathies. Although tau protein is highly enriched in neurons and poorly expressed by astrocytes, the ...
Lire la suite >Deposits of different abnormal forms of tau in neurons and astrocytes represent key anatomo-pathological features of tauopathies. Although tau protein is highly enriched in neurons and poorly expressed by astrocytes, the origin of astrocytic tau is still elusive. Here, we used innovative gene transfer tools to model tauopathies in adult mouse brains and to investigate the origin of astrocytic tau. We showed in our adeno-associated virus (AAV)-based models and in Thy-Tau22 transgenic mice that astrocytic tau pathology can emerge secondarily to neuronal pathology. By designing an in vivo reporter system, we further demonstrated bidirectional exchanges of tau species between neurons and astrocytes. We then determined the consequences of tau accumulation in astrocytes on their survival in models displaying various status of tau aggregation. Using stereological counting of astrocytes, we report that, as for neurons, soluble tau species are highly toxic to some subpopulations of astrocytes in the hippocampus, whereas the accumulation of tau aggregates does not affect their survival. Thus, astrocytes are not mere bystanders of neuronal pathology. Our results strongly suggest that tau pathology in astrocytes may significantly contribute to clinical symptoms.Lire moins >

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Date de dépôt :

2024-11-29T22:02:20Z
2024-12-10T09:49:28Z