Title :

Bone Marrow Adiposity Alterations in Postmenopausal Women With Type 2 Diabetes Are Site-Specific

Author(s) :

Badr, Sammy [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Cotten, Anne [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]
Lombardo, Daniela [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Ruschke, S. [Auteur]
Karampinos, D. C. [Auteur]
Ramdane, Nassima [Auteur]
Service de Biostatistiques [CHRU Lille]
Genin, Michaël [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Paccou, Julien [Auteur]
Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab]

Journal title :

Journal of the Endocrine Society

Pages :

-

Publication date :

2024-11-18

ISSN :

2472-1972

English keyword(s) :

bone marrow adipose tissue
diabetes mellitus
glycated hemoglobin
bone mineral density
osteoporosis

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

ContextBone marrow adiposity (BMAT) alterations in patients with type 2 diabetes mellitus (T2DM) may contribute to adverse bone effects.ObjectiveCharacterization of BMAT content and composition in patients with well-controlled ...
Show more >ContextBone marrow adiposity (BMAT) alterations in patients with type 2 diabetes mellitus (T2DM) may contribute to adverse bone effects.ObjectiveCharacterization of BMAT content and composition in patients with well-controlled T2DM.MethodsThis cross-sectional study included 2 groups of postmenopausal women: one with T2DM and the other without. The proton density fat fraction (PDFF) of the lumbar spine and proximal femur, comprising the femoral head, neck, and diaphysis, was assessed using chemical shift-based water-fat separation imaging (WFI). Magnetic resonance imaging with spectroscopy (1H-MRS) was performed in a subgroup of participants to confirm the PDFF measurements and determine the apparent lipid unsaturation level (aLUL) at the L3 vertebrae and femoral neck. The association of imaging-based PDFFs and aLUL between diabetes groups was investigated by adjusting for confounding factors using a linear mixed model.ResultsAmong 199 participants, patients with T2DM (n = 29) were significantly heavier (P < .001) and had a higher bone mineral density (BMD) (P < .001 for all sites) than nondiabetic patients (n = 170). When PDFFs were compared after adjusting for age, body mass index (BMI), and BMD, the femoral head WFI-based PDFF was lower in patients with T2DM (mean [standard error] 88.0% [0.7] vs 90.6% [0.3], P < .001). Moreover, the aLUL at the L3 vertebrae was lower in patients with T2DM (n = 16) than in without (n = 97) (mean [standard error] 3.9% [0.1] vs 4.3% [0.1], P = .02).ConclusionThe content and composition of BMAT are modified in postmenopausal women with T2DM and these changes occur at specific sites.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Collections :

• Marrow Adiposity & Bone Lab (MABLab) - ULR 4490

Source :

Harvested from HAL