Micro-alloying of Zn and Ca in vacuum ...
Document type :
Article dans une revue scientifique
Permalink :
Title :
Micro-alloying of Zn and Ca in vacuum induction casted bioresorbable Mg system: Perspectives on corrosion resistance, cytocompatibility, and inflammatory response
Author(s) :
Behera, Manisha [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Denys, Agnes [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Shabadi, Rajashekhara [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Allain, Fabrice [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
GRUESCU, Cosmin [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207

Unité Matériaux et Transformations - UMR 8207 [UMET]
Denys, Agnes [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Shabadi, Rajashekhara [Auteur]

Unité Matériaux et Transformations (UMET) - UMR 8207
Allain, Fabrice [Auteur]

Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
GRUESCU, Cosmin [Auteur]

Unité Matériaux et Transformations (UMET) - UMR 8207
Journal title :
Journal of Magnesium and Alloys
Abbreviated title :
Journal of Magnesium and Alloys
Volume number :
12
Pages :
2812-2825
Publisher :
Elsevier BV
Publication date :
2024-07
ISSN :
2213-9567
HAL domain(s) :
Sciences du Vivant [q-bio]
Chimie/Matériaux
Chimie/Matériaux
English abstract : [en]
There is an increasing interest in biodegradable materials, such as magnesium, for orthopaedic implants. This is driven by their potential to address challenges like stress shielding and the need for secondary removal ...
Show more >There is an increasing interest in biodegradable materials, such as magnesium, for orthopaedic implants. This is driven by their potential to address challenges like stress shielding and the need for secondary removal surgery. In this study, biodegradable magnesium alloys were produced using the Vacuum Induction Casting technique. The impact of micro-alloying Zn and Ca in Mgsingle bondxZnsingle bond0.2Ca (x = 0.1, 0.2, 0.3, and 0.4 wt%) alloys on corrosion resistance, cytocompatibility, and early-stage inflammatory response was investigated. XRD and SEM-EDS analysis confirmed the presence of Ca2Mg6Zn3 secondary phases in all alloys. The Mgsingle bond0.3Znsingle bond0.2Ca alloy exhibited the lowest corrosion rate and an elastic modulus of 36.8 GPa, resembling that of natural bone. Electrochemical measurements indicated a correlation between grain size and secondary phase volume fraction in explaining corrosion behaviour. In vitro degradation in simulated body fluid (SBF) for 21 days showed hydroxyapatite formation on alloy surfaces, aligning with electrochemical studies. In vitro cytotoxicity tests demonstrated the cytocompatibility of all alloys, with Mgsingle bond0.3Znsingle bond0.2Ca having the highest cell viability over a 6-day cell culture. Investigation into the inflammatory response with RAW-Blue macrophages revealed the anti-inflammatory properties of Mgsingle bond0.3Znsingle bond0.2Ca alloys. Micro-alloying with 0.3 wt% Zn and 0.2 wt% Ca enhanced mechanical properties, corrosion resistance, cytocompatibility, and immunomodulatory properties. This positions the Mgsingle bond0.3Znsingle bond0.2Ca alloy as a promising biodegradable implant for bone fixation applications.Show less >
Show more >There is an increasing interest in biodegradable materials, such as magnesium, for orthopaedic implants. This is driven by their potential to address challenges like stress shielding and the need for secondary removal surgery. In this study, biodegradable magnesium alloys were produced using the Vacuum Induction Casting technique. The impact of micro-alloying Zn and Ca in Mgsingle bondxZnsingle bond0.2Ca (x = 0.1, 0.2, 0.3, and 0.4 wt%) alloys on corrosion resistance, cytocompatibility, and early-stage inflammatory response was investigated. XRD and SEM-EDS analysis confirmed the presence of Ca2Mg6Zn3 secondary phases in all alloys. The Mgsingle bond0.3Znsingle bond0.2Ca alloy exhibited the lowest corrosion rate and an elastic modulus of 36.8 GPa, resembling that of natural bone. Electrochemical measurements indicated a correlation between grain size and secondary phase volume fraction in explaining corrosion behaviour. In vitro degradation in simulated body fluid (SBF) for 21 days showed hydroxyapatite formation on alloy surfaces, aligning with electrochemical studies. In vitro cytotoxicity tests demonstrated the cytocompatibility of all alloys, with Mgsingle bond0.3Znsingle bond0.2Ca having the highest cell viability over a 6-day cell culture. Investigation into the inflammatory response with RAW-Blue macrophages revealed the anti-inflammatory properties of Mgsingle bond0.3Znsingle bond0.2Ca alloys. Micro-alloying with 0.3 wt% Zn and 0.2 wt% Ca enhanced mechanical properties, corrosion resistance, cytocompatibility, and immunomodulatory properties. This positions the Mgsingle bond0.3Znsingle bond0.2Ca alloy as a promising biodegradable implant for bone fixation applications.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Collections :
Research team(s) :
Diversité structurale des héparanes sulfates et régulation de la réponse inflammatoire
Submission date :
2025-01-20T12:43:10Z
2025-01-22T07:46:56Z
2025-01-22T07:46:56Z
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