Titre :

Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment

Auteur(s) :

Kappel, Ben [Auteur]
Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] [UKA]
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
de Angelis, Lorenzo [Auteur]
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
Heiser, Michael [Auteur]
Metabolomic discoveries GmbH
Metabolon Inc.
Ballanti, Marta [Auteur]
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
Stoehr, Robert [Auteur]
Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] [UKA]
Goettsch, Claudia [Auteur]
Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] [UKA]
Mavilio, Maria [Auteur]
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
Artati, Anna [Auteur]
Helmholtz Zentrum München = German Research Center for Environmental Health [HMGU]
Paoluzi, Omero [Auteur]
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
Adamski, Jerzy [Auteur]
German Center for Diabetes Research - Deutsches Zentrum für Diabetesforschung [Neuherberg] [DZD]
Helmholtz Zentrum München = German Research Center for Environmental Health [HMGU]
National University of Singapore [NUS]
Technische Universität Munchen - Technical University Munich - Université Technique de Munich [TUM]
Mingrone, Geltrude [Auteur]
King‘s College London
Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] [Unicatt]
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Staels, Bart [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Burcelin, Rémy [Auteur]
Institut des Maladies Métaboliques et Cardiovasculaires [I2MC]
Monteleone, Giovanni [Auteur]
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
Menghini, Rossella [Auteur]
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
Marx, Nikolaus [Auteur]
Universitätsklinikum RWTH Aachen - University Hospital Aachen [Aachen, Germany] [UKA]
Federici, Massimo [Auteur]
Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]

Titre de la revue :

Molecular metabolism

Pagination :

100976

Éditeur :

Elsevier

Date de publication :

2020-06

ISSN :

2212-8778

Mot(s)-clé(s) en anglais :

Atherosclerosis
Antibiotics
Gut microbiota
Dysbiosis
Metabolic diversity
Cross-omics

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Cardiologie et système cardiovasculaire

Résumé en anglais : [en]

ObjectiveThe metabolic influence of gut microbiota plays a pivotal role in the pathogenesis of cardiometabolic diseases. Antibiotics affect intestinal bacterial diversity, and long-term usage has been identified as an ...
Lire la suite >ObjectiveThe metabolic influence of gut microbiota plays a pivotal role in the pathogenesis of cardiometabolic diseases. Antibiotics affect intestinal bacterial diversity, and long-term usage has been identified as an independent risk factor for atherosclerosis-driven events. The aim of this study was to explore the interaction between gut dysbiosis by antibiotics and metabolic pathways with the impact on atherosclerosis development.MethodsWe combined oral antibiotics with different diets in an Apolipoprotein E-knockout mouse model linking gut microbiota to atherosclerotic lesion development via an integrative cross-omics approach including serum metabolomics and cecal 16S rRNA targeted metagenomic sequencing. We further investigated patients with carotid atherosclerosis compared to control subjects with comparable cardiovascular risk.ResultsHere, we show that increased atherosclerosis by antibiotics was connected to a loss of intestinal diversity and alterations of microbial metabolic functional capacity with a major impact on the host serum metabolome. Pathways that were modulated by antibiotics and connected to atherosclerosis included diminished tryptophan and disturbed lipid metabolism. These pathways were related to the reduction of certain members of Bacteroidetes and Clostridia by antibiotics in the gut. Patients with atherosclerosis presented a similar metabolic signature as those induced by antibiotics in our mouse model.ConclusionTaken together, this work provides insights into the complex interaction between intestinal microbiota and host metabolism. Our data highlight that detrimental effects of antibiotics on the gut flora are connected to a pro-atherogenic metabolic phenotype beyond classical risk factors.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL

Date de dépôt :

2025-01-22T22:41:25Z