Title :

Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition

Author(s) :

Mayeur, Sylvain [Auteur]
Wattez, Jean-Sébastien [Auteur]
Lukaszewski, Marie-Amelie [Auteur]
Lecoutre, Simon [Auteur]
Butruille, Laura [Auteur]
Drougard, Anne [Auteur]
Eberle, Delphine [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Physiologie Cellulaire (PHYCEL) - U1003
Bastide, Bruno [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369
Laborie, Christine [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement Périnatal et Santé - EA 4489
Storme, Laurent [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement Périnatal et Santé - EA 4489
Knauf, Claude [Auteur]
Vieau, didier [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement Périnatal et Santé - EA 4489
Breton, Christophe [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement Périnatal et Santé - EA 4489
Lesage, Jean [Auteur]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement périnatal et croissance - EA 4489 [EPS]
Environnement Périnatal et Santé - EA 4489

Journal title :

Diabetes

Abbreviated title :

Diabetes

Volume number :

65

Pages :

554-560

Publication date :

2016-03-01

ISSN :

0012-1797
1939-327X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The adequate control of glucose homeostasis during both gestation and early postnatal life is crucial for the development of the fetoplacental unit and adaptive physiological responses at birth. Growing evidences indicate ...
Show more >The adequate control of glucose homeostasis during both gestation and early postnatal life is crucial for the development of the fetoplacental unit and adaptive physiological responses at birth. Growing evidences indicate that apelin and its receptor, APJ, which are expressed across a wide range of tissues, exert important roles in glucose homeostasis in adults. However, little is known about the function of the apelinergic system during gestation. In this study, we evaluated the activity of this system in rats, the role of apelin in fetal and neonatal glucose homeostasis, and its modulation by maternal food restriction. We found that 1) the apelinergic system was expressed at the fetoplacental interface and in numerous fetal tissues, 2) ex vivo, the placenta released high amounts of apelin in late gestation, 3) intravenous apelin injection in mothers increased the transplacental transport of glucose, and 4) intraperitoneal apelin administration in neonates increased glucose uptake in lung and muscle. Maternal food restriction drastically reduced apelinemia in both mothers and growth-restricted fetuses and altered the expression of the apelinergic system at the fetoplacental interface. Together, our data demonstrate that apelin controls fetal and neonatal glucose homeostasis and is altered by fetal growth restriction induced by maternal undernutrition.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Univ. Littoral Côte d’Opale
Univ. Artois
Université de Lille

Collections :

• Environnement Périnatal et Santé - ULR 4489
• Physiologie Cellulaire (PHYCELL) - U1003
• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Research team(s) :

Activité Physique, Muscle, Santé (APMS)

Submission date :

2019-09-24T10:01:42Z