Mild Intrauterine Hypoperfusion Leads to ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
Mild Intrauterine Hypoperfusion Leads to Lumber and Cortical Hyperexcitability, Spasticity, and Muscle Dysfunctions in Rats: Implications for Prematurity
Auteur(s) :
Coq, Jacques-Olivier [Auteur]
Institut de Neurosciences de la Timone [INT]
Delcour, Maxime [Auteur]
Aix Marseille Université [AMU]
Ogawa, Yuko [Auteur]
Peyronnet, Julie [Auteur]
Institut de Neurosciences de la Timone [INT]
Castets, Francis [Auteur]
Aix Marseille Université [AMU]
Turle-Lorenzo, Nathalie [Auteur]
Aix Marseille Université [AMU]
Montel, Valerie [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Bodineau, Laurence [Auteur]
Sorbonne Université [SU]
Cardot, Phillipe [Auteur]
Sorbonne Université [SU]
Brocard, Cecile [Auteur]
Institut de Neurosciences de la Timone [INT]
Liabeuf, Sylvie [Auteur]
Institut de Neurosciences de la Timone [INT]
Bastide, Bruno [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Canu, Marie-Helene [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Tsuji, Masahiro [Auteur]
Cayetanot, Florence [Auteur]
Institut de Neurosciences de la Timone [INT]
Institut de Neurosciences de la Timone [INT]
Delcour, Maxime [Auteur]
Aix Marseille Université [AMU]
Ogawa, Yuko [Auteur]
Peyronnet, Julie [Auteur]
Institut de Neurosciences de la Timone [INT]
Castets, Francis [Auteur]
Aix Marseille Université [AMU]
Turle-Lorenzo, Nathalie [Auteur]
Aix Marseille Université [AMU]
Montel, Valerie [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Bodineau, Laurence [Auteur]
Sorbonne Université [SU]
Cardot, Phillipe [Auteur]
Sorbonne Université [SU]
Brocard, Cecile [Auteur]
Institut de Neurosciences de la Timone [INT]
Liabeuf, Sylvie [Auteur]
Institut de Neurosciences de la Timone [INT]
Bastide, Bruno [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Canu, Marie-Helene [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Tsuji, Masahiro [Auteur]
Cayetanot, Florence [Auteur]
Institut de Neurosciences de la Timone [INT]
Titre de la revue :
Frontiers in neurology
Nom court de la revue :
Front. Neurol.
Numéro :
9
Date de publication :
2018-06-15
ISSN :
1664-2295
Mot(s)-clé(s) en anglais :
cerebral palsy
white matter injury
intrauterine growth retardation
KCC2
neonatal hypoxia-ischemia
white matter injury
intrauterine growth retardation
KCC2
neonatal hypoxia-ischemia
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Intrauterine ischemia-hypoxia is detrimental to the developing brain and leads to white matter injury (WMI), encephalopathy of prematurity (EP), and often to cerebral palsy (CP), but the related pathophysiological mechanisms ...
Lire la suite >Intrauterine ischemia-hypoxia is detrimental to the developing brain and leads to white matter injury (WMI), encephalopathy of prematurity (EP), and often to cerebral palsy (CP), but the related pathophysiological mechanisms remain unclear. In prior studies, we used mild intrauterine hypoperfusion (MIUH) in rats to successfully reproduce the diversity of clinical signs of EP, and some CP symptoms. Briefly, MIUH led to inflammatory processes, diffuse gray and WMI, minor locomotor deficits, musculoskeletal pathologies, neuroanatomical and functional disorganization of the primary somatosensory and motor cortices, delayed sensorimotor reflexes, spontaneous hyperactivity, deficits in sensory information processing, memory and learning impairments. In the present study, we investigated the early and long-lasting mechanisms of pathophysiology that may be responsible for the various symptoms induced by MIUH. We found early hyperreflexia, spasticity and reduced expression of KCC2 (a chloride cotransporter that regulates chloride homeostasis and cell excitability). Adult MIUH rats exhibited changes in muscle contractile properties and phenotype, enduring hyperreflexia and spasticity, as well as hyperexcitability in the sensorimotor cortex. Taken together, these results show that reduced expression of KCC2, lumbar hyperreflexia, spasticity, altered properties of the soleus muscle, as well as cortical hyperexcitability may likely interplay into a self-perpetuating cycle, leading to the emergence, and persistence of neurodevelopmental disorders (NDD) in EP and CP, such as sensorimotor impairments, and probably hyperactivity, attention, and learning disorders.Lire moins >
Lire la suite >Intrauterine ischemia-hypoxia is detrimental to the developing brain and leads to white matter injury (WMI), encephalopathy of prematurity (EP), and often to cerebral palsy (CP), but the related pathophysiological mechanisms remain unclear. In prior studies, we used mild intrauterine hypoperfusion (MIUH) in rats to successfully reproduce the diversity of clinical signs of EP, and some CP symptoms. Briefly, MIUH led to inflammatory processes, diffuse gray and WMI, minor locomotor deficits, musculoskeletal pathologies, neuroanatomical and functional disorganization of the primary somatosensory and motor cortices, delayed sensorimotor reflexes, spontaneous hyperactivity, deficits in sensory information processing, memory and learning impairments. In the present study, we investigated the early and long-lasting mechanisms of pathophysiology that may be responsible for the various symptoms induced by MIUH. We found early hyperreflexia, spasticity and reduced expression of KCC2 (a chloride cotransporter that regulates chloride homeostasis and cell excitability). Adult MIUH rats exhibited changes in muscle contractile properties and phenotype, enduring hyperreflexia and spasticity, as well as hyperexcitability in the sensorimotor cortex. Taken together, these results show that reduced expression of KCC2, lumbar hyperreflexia, spasticity, altered properties of the soleus muscle, as well as cortical hyperexcitability may likely interplay into a self-perpetuating cycle, leading to the emergence, and persistence of neurodevelopmental disorders (NDD) in EP and CP, such as sensorimotor impairments, and probably hyperactivity, attention, and learning disorders.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Univ. Littoral Côte d’Opale
Univ. Artois
Université de Lille
Univ. Artois
Université de Lille
Équipe(s) de recherche :
Activité Physique, Muscle, Santé (APMS)
Date de dépôt :
2019-09-24T10:01:47Z
2020-06-02T09:12:37Z
2020-06-02T09:12:37Z
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- fneur-09-00423.pdf
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