MPAgenomics : An R package for multi-patients ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Title :
MPAgenomics : An R package for multi-patients analysis of genomic markers
Author(s) :
Grimonprez, Quentin [Auteur]
MOdel for Data Analysis and Learning [MODAL]
Celisse, Alain [Auteur]
Laboratoire Paul Painlevé - UMR 8524 [LPP]
MOdel for Data Analysis and Learning [MODAL]
Blanck, Samuel [Auteur]
MOdel for Data Analysis and Learning [MODAL]
Cheok, Meyling [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Figeac, Martin [Auteur]
Plateforme de génomique fonctionnelle et structurelle [Lille]
Marot, Guillemette [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
MOdel for Data Analysis and Learning [MODAL]
MOdel for Data Analysis and Learning [MODAL]
Celisse, Alain [Auteur]
Laboratoire Paul Painlevé - UMR 8524 [LPP]
MOdel for Data Analysis and Learning [MODAL]
Blanck, Samuel [Auteur]
MOdel for Data Analysis and Learning [MODAL]
Cheok, Meyling [Auteur]

Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Figeac, Martin [Auteur]

Plateforme de génomique fonctionnelle et structurelle [Lille]
Marot, Guillemette [Auteur]

Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
MOdel for Data Analysis and Learning [MODAL]
Journal title :
BMC Bioinformatics
Pages :
394
Publisher :
BioMed Central
Publication date :
2014-12
ISSN :
1471-2105
English keyword(s) :
segmentation
normalization
calling
genomic markers selection
SNP array
multi patient analysis
normalization
calling
genomic markers selection
SNP array
multi patient analysis
HAL domain(s) :
Sciences du Vivant [q-bio]/Bio-Informatique, Biologie Systémique [q-bio.QM]
English abstract : [en]
MPAgenomics, standing for multi-patients analysis (MPA) of genomic markers, is an R-package devoted to: (i) efficient segmentation, and (ii) genomic marker selection from multi-patient copy number and SNP data profiles. ...
Show more >MPAgenomics, standing for multi-patients analysis (MPA) of genomic markers, is an R-package devoted to: (i) efficient segmentation, and (ii) genomic marker selection from multi-patient copy number and SNP data profiles. It provides wrappers from commonly used packages to facilitate their repeated (sometimes difficult) use, offering an easy-to-use pipeline for beginners in R. The segmentation of successive multiple profiles (finding losses and gains) is based on a new automatic choice of influential parameters since default ones were misleading in the original packages. Considering multiple profiles in the same time, MPAgenomics wraps efficient penalized regression methods to select relevant markers associated with a given response.Show less >
Show more >MPAgenomics, standing for multi-patients analysis (MPA) of genomic markers, is an R-package devoted to: (i) efficient segmentation, and (ii) genomic marker selection from multi-patient copy number and SNP data profiles. It provides wrappers from commonly used packages to facilitate their repeated (sometimes difficult) use, offering an easy-to-use pipeline for beginners in R. The segmentation of successive multiple profiles (finding losses and gains) is based on a new automatic choice of influential parameters since default ones were misleading in the original packages. Considering multiple profiles in the same time, MPAgenomics wraps efficient penalized regression methods to select relevant markers associated with a given response.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Collections :
Source :
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