Titre :

Aluminum exposure alters oocytes spindle, and tadpole behavior with modifications of proteasome and oxidative stress markers in Xenopus laevis

Auteur(s) :

Douchez, Pélagie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Closset, Marie [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Martoriati, Alain [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 [UGSF]
Fliniaux, Ingrid [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Uchimura, Yoshiko [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Marin, Matthieu [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Douchez, Pélagie [Auteur]

Titre de la revue :

Chemosphere

Nom court de la revue :

Chemosphere

Numéro :

374

Pagination :

144218

Éditeur :

Elsevier BV

Date de publication :

2025-04

ISSN :

0045-6535

Mot(s)-clé(s) en anglais :

Xenopus laevis
Aluminum stress
Aquatic toxicology
Oocyte maturation
Fertilization
Early development

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Aluminum, a non-essential metal, identified as potentially toxic to organisms, is increasingly released and accumulated into the aquatic ecosystems as a result of human activities. However, only a few data are available ...
Lire la suite >Aluminum, a non-essential metal, identified as potentially toxic to organisms, is increasingly released and accumulated into the aquatic ecosystems as a result of human activities. However, only a few data are available regarding its action in aquatic vertebrates during their early stages of development. In order to further investigate the toxicity mechanisms induced by this metal, we used a relevant model in ecotoxicology Xenopus laevis. Oocytes and embryos were exposed to aluminum sulfate (Al2(SO4)3), at various concentrations, ranging from environmentally relevant levels to those known to cause toxicity. The results indicate that during oocyte maturation, abnormalities in meiotic spindles were observed at concentrations ranging from 0.05 to 50 mg/L. At these exposure concentrations, the fertilization efficiency, phenotypes and cardiac rhythms of tadpoles were not affected. On the contrary, at 50 mg/L, the behavior of 6 days tadpoles was modified towards a longer hypoactivity. Concomitantly, Western blot analysis showed that heat shock Hsp70 and proteasome Rpn10 were increased, while, oxidative stress markers Sod1, Gst, and Nrf2 were decreased. Our work identifies aluminum as a threat to oocyte maturation and tadpole behavior in Xenopus laevis potentially impacting their population dynamics. Moreover, Nrf2 and Rpn10 are uncovered as potential toxicity markers for this early tadpole period and could serve to evaluate aluminum exposure in aquatic species.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Régulation des signaux de division

Date de dépôt :

2025-03-05T08:54:03Z
2025-03-05T09:23:04Z