Title :

Cardiogenic Shock Risk Score at Diagnosis of Multisystem Inflammatory Syndrome in Children: A Multicenter Study

Author(s) :

Bichali, S. [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
CHU Sainte Justine [Montréal]
Ouldali, N. [Auteur]
Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables [ECEVE (U1123 / UMR_S_1123)]
CHU Sainte Justine [Montréal]
Genin, Michaël [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Toubiana, J. [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Belot, A. [Auteur]
Centre de Référence pour les Maladies Rhumatologiques Auto-Immunes et Systémiques [CHU Necker] [RAISE]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Levy, C. [Auteur]
Groupe de Pathologie Infectieuse Pédiatrique [Paris] [GPIP]
CHI Créteil
Association Clinique et Thérapeutique Infantile du Val de Marne [ACTIV]
Rybak, A. [Auteur]
Division de cardiologie [CHU Vaudois] [CHUV]
Association Clinique et Thérapeutique Infantile du Val de Marne [ACTIV]
Giroux, N. [Auteur]
Centre Hospitalier Universitaire de Nancy [CHU Nancy]
Béchet, S. [Auteur]
Association Clinique et Thérapeutique Infantile du Val de Marne [ACTIV]
Javouhey, E. [Auteur]
Hospices Civils de Lyon [HCL]
Angoulvant, F. [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Groupe de Pathologie Infectieuse Pédiatrique [Paris] [GPIP]
Division de cardiologie [CHU Vaudois] [CHUV]
Godart, Francois [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Houeijeh, Ali [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Leteurtre, Stephane [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]

Journal title :

Pediatr. Cardiol.

Abbreviated title :

Pediatr. Cardiol.

Volume number :

-

Pages :

-

Publication date :

2025-03-22

ISSN :

0172-0643

English keyword(s) :

Heart failure
Inotrope
Prediction
COVID-19
SARS-CoV-2
PIMS

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Severe cardiovascular involvement is associated with mortality in multisystem inflammatory syndrome in children (MIS-C). This study aimed to test a previously published cardiogenic shock risk score at diagnosis of MIS-C ...
Show more >Severe cardiovascular involvement is associated with mortality in multisystem inflammatory syndrome in children (MIS-C). This study aimed to test a previously published cardiogenic shock risk score at diagnosis of MIS-C and build a new screening tool in a larger pediatric cohort. The first score published in a single-center cohort (age > 8 years, time to diagnosis ≥ 6 days, and NT-proBNP at diagnosis ≥ 11.103 ng/L) was tested in a multicenter cohort of pediatric patients diagnosed with MIS-C from 2020 to 2023. In the multicenter cohort, the factors associated with the occurrence of cardiogenic shock were determined and a new score was built using a multivariate regression model. In 127 children with MIS-C, (median age [interquartile range] 8.6 [5.2; 11.5] years, 67 (53%) patients with cardiogenic shock), age > 8 years, time to treatment ≥ 6 days, dyspnea, altered mental status, general deterioration, gastrointestinal symptoms, ≤ 1 Kawasaki sign, absence of rhinopharyngitis signs, NT-proBNP ≥ 11.103 ng/L, high C-Reactive Protein (CRP), and high leucocytes at diagnosis of MIS-C were associated with a high risk of cardiogenic shock. The new score was 0.128*Age(year) + 1.195*(1 if dyspnea, 0 otherwise) + 0.007*CRP(mg/L) − 2.6732. The sensitivity was 0.88 and negative likelihood ratio 0.23 (cutoff − 0.4761). The score correlated with the minimal left ventricular ejection fraction (ρ = 0.51, p < 0.001). In a multicenter cohort, each item of the previous score was associated with the occurrence of cardiogenic shock. The new score, combining age, dyspnea, and CRP at diagnosis of MIS-C, had a high sensitivity.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2025-03-25T22:05:58Z
2025-04-07T07:22:51Z