Title :

Efficient in situ N-heterocyclic carbene palladium(ii) generated from Pd(OAc)2 catalysts for carbonylative Suzuki coupling reactions of arylboronic acids with 2-bromopyridine under inert conditions leading to unsymmetrical arylpyridine ketones: synthesis, characterization and cytotoxic activities

Author(s) :

Touj, Nedra [Auteur]
Innov'com, Sup'com, University of Carthage Ariana, Tunis, Tunisia
Al-Ayed, Abdullah S. [Auteur]
Qassim University [Kingdom of Saudi Arabia]
Sauthier, Mathieu [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Mansour, Lamjed [Auteur]
Qassim University [Kingdom of Saudi Arabia]
Harrath, Abdel Halim [Auteur]
Qassim University [Kingdom of Saudi Arabia]
Al-Tamimi, Jamil [Auteur]
Qassim University [Kingdom of Saudi Arabia]
Özdemir, Ismail [Auteur]
Inönü University
Yaşar, Sedat [Auteur]
Inönü University
Hamdi, Naceur [Auteur]
Qassim University [Kingdom of Saudi Arabia]
Innov'com, Sup'com, University of Carthage Ariana, Tunis, Tunisia

Journal title :

RSC Advances

Abbreviated title :

RSC Adv.

Volume number :

8

Pages :

40000-40015

Publisher :

Royal Society of Chemistry (RSC)

Publication date :

2018-12-05

HAL domain(s) :

Chimie/Catalyse

English abstract : [en]

N,N-Substituted benzimidazole salts were successfully synthesized and characterized by 1H-NMR, 13C {1H} NMR and IR techniques, which support the proposed structures. Catalysts generated in situ were efficiently used for ...
Show more >N,N-Substituted benzimidazole salts were successfully synthesized and characterized by 1H-NMR, 13C {1H} NMR and IR techniques, which support the proposed structures. Catalysts generated in situ were efficiently used for the carbonylative cross-coupling reaction of 2 bromopyridine with various boronic acids. The reaction was carried out in THF at 110 °C in the presence of K2CO3 under inert conditions and yields unsymmetrical arylpyridine ketones. All N,N-substituted benzimidazole salts 2a–i and 4a–i studied in this work were screened for their cytotoxic activities against human cancer cell lines such us MDA-MB-231, MCF-7 and T47D. The N,N-substituted benzimidazoles 2e and 2f exhibited the most cytotoxic effect with promising cytotoxic activity with IC50 values of 4.45 μg mL−1 against MDA-MB-231 and 4.85 μg mL−1 against MCF7 respectively.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

ENSCL
CNRS
Centrale Lille
Univ. Artois
Université de Lille

Collections :

• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Research team(s) :

Catalyse et synthèse éco-compatible (CASECO)

Submission date :

2019-09-25T15:07:02Z
2021-03-18T10:04:17Z