Title :

T-cell impact on acute GVHD incidence following haplo-HCT after reduced intensity conditioning and posttransplant cyclophosphamide.

Author(s) :

Varlet, Pauline [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Alsuliman, Tamim [Auteur]
Trauet, Jacques [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Demaret, Julie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Labalette, Myriam [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Bone marrow transplantation

Abbreviated title :

Bone Marrow Transplant.

Publication date :

2019-03-19

ISSN :

1476-5365

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

In previous studies, we and others observed in patients undergoing HLA-matched hematopoietic cell transplantation that high proportion of donor-derived CD4 /CCR7 T cells were associated with an increased risk of acute ...
Show more >In previous studies, we and others observed in patients undergoing HLA-matched hematopoietic cell transplantation that high proportion of donor-derived CD4 /CCR7 T cells were associated with an increased risk of acute GVHD without any interference in relapse incidence. We investigated the impact of donor-derived CD4 /CCR7 T cells on patient outcome in haploidentical settings where posttransplant cyclophosphamide is used. We analyzed T-cell subsets in grafts of 29 adult patients who underwent first haploidentical transplant following reduced intensity conditioning. The median CD4 /CCR7 subset proportion was 69.2% among donor CD4 T cells. With a median follow-up of 28.1 months (range: 11.0-44.3), 16 patients (55%) developed acute GVHD; this includes 5 patients with grade 3 acute GVHD. Fifty-four percent of patients who received > 69.2% of CD4 /CCR7 T cells and 12% of patients who received < 69.2% CD4 /CCR7 T cells developed acute GVHD (p = 0.028). In multivariate analysis, a high proportion of CD4 /CCR7 T cells was the only factor that impacted acute GVHD (HR = 4.925, 95% CI [1.020-23.775], p = 0,047) with no impact on overall survival. Our results confirm the impact of a high proportion of CD4 /CCR7 T cells on acute GVHD incidence in patients undergoing haploidentical transplant despite the use of posttransplant cyclophosphamide.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2019-10-22T07:44:29Z