Evaluation of outcomes in renal transplantation ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Evaluation of outcomes in renal transplantation with hypothermic machine perfusion for the preservation of kidneys from expanded-criteria donors.
Auteur(s) :
Savoye, Emilie [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Macher, Marie-Alice [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Videcoq, Michel [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Gatault, Philippe [Auteur]
Hazzan, Marc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Abboud, Imad [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Thierry, Antoine [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Bertrand, Dominique [Auteur]
CHU Rouen
Drouin, Sarah [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Sayegh, Johnny [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Barrou, Benoit [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Badet, Lionel [Auteur]
Hospices Civils de Lyon [HCL]
Bastien, Olivier [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Lamotte, Christian [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Logerot, Helene [Auteur]
Legeai, Camille [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Antoine, Corinne [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Agence de la biomédecine [Saint-Denis la Plaine]
Macher, Marie-Alice [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Videcoq, Michel [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Gatault, Philippe [Auteur]
Hazzan, Marc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Abboud, Imad [Auteur]
Hopital Saint-Louis [AP-HP] [AP-HP]
Thierry, Antoine [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Bertrand, Dominique [Auteur]
CHU Rouen
Drouin, Sarah [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Sayegh, Johnny [Auteur]
Centre Hospitalier Universitaire d'Angers [CHU Angers]
Barrou, Benoit [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
Badet, Lionel [Auteur]
Hospices Civils de Lyon [HCL]
Bastien, Olivier [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Lamotte, Christian [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Logerot, Helene [Auteur]
Legeai, Camille [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Antoine, Corinne [Auteur]
Agence de la biomédecine [Saint-Denis la Plaine]
Titre de la revue :
Clinical Transplantation
Nom court de la revue :
Clin Transplant
Numéro :
33
Pagination :
e13536
Date de publication :
2019-05
ISSN :
1399-0012
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
In 2012, an expert working group from the French Transplant Health Authority recommended the use of hypothermic machine perfusion (HMP) to improve kidney preservation and transplant outcomes from expanded criteria donors, ...
Lire la suite >In 2012, an expert working group from the French Transplant Health Authority recommended the use of hypothermic machine perfusion (HMP) to improve kidney preservation and transplant outcomes from expanded criteria donors, deceased after brain death. This study compares HMP and cold storage (CS) effects on delayed graft function (DGF) and transplant outcomes. We identified 4,316 kidney transplants from expanded criteria donors (2011-2014) in France through the French Transplant Registry. DGF occurrence was analyzed with a logistic regression, excluding preemptive transplants. One-year graft failure was analyzed with a Cox regression. A subpopulation of 66 paired kidneys was identified: one preserved by HMP and the other by CS from the same donor. Kidneys preserved by HMP (801) vs CS (3515) were associated with more frequent recipient comorbidities and older donors and recipients. HMP had a protective effect against DGF (24% in HMP group and 38% in CS group, OR = 0.49 [0.40-0.60]). Results were similar in the paired kidneys (OR = 0.23 [0.04-0.57]). HMP use decreased risk for 1-year graft failure (HR = 0.77 [0.60-0.99]). Initial hospital stays were shorter in the HMP group (P < 0.001). Our results confirm the reduction in DGF occurrence among expanded criteria donors kidneys preserved by HMP.Lire moins >
Lire la suite >In 2012, an expert working group from the French Transplant Health Authority recommended the use of hypothermic machine perfusion (HMP) to improve kidney preservation and transplant outcomes from expanded criteria donors, deceased after brain death. This study compares HMP and cold storage (CS) effects on delayed graft function (DGF) and transplant outcomes. We identified 4,316 kidney transplants from expanded criteria donors (2011-2014) in France through the French Transplant Registry. DGF occurrence was analyzed with a logistic regression, excluding preemptive transplants. One-year graft failure was analyzed with a Cox regression. A subpopulation of 66 paired kidneys was identified: one preserved by HMP and the other by CS from the same donor. Kidneys preserved by HMP (801) vs CS (3515) were associated with more frequent recipient comorbidities and older donors and recipients. HMP had a protective effect against DGF (24% in HMP group and 38% in CS group, OR = 0.49 [0.40-0.60]). Results were similar in the paired kidneys (OR = 0.23 [0.04-0.57]). HMP use decreased risk for 1-year graft failure (HR = 0.77 [0.60-0.99]). Initial hospital stays were shorter in the HMP group (P < 0.001). Our results confirm the reduction in DGF occurrence among expanded criteria donors kidneys preserved by HMP.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
Inserm
Université de Lille
Inserm
Université de Lille
Date de dépôt :
2019-10-22T07:44:33Z
2024-04-29T13:13:31Z
2024-04-29T13:13:31Z