Title :

Impact of amorphisation methods on the physico-chemical properties of amorphous lactulose

Author(s) :

Ngono, Frederic [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Willart, Jean-François [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Cuello, Gabriel J. [Auteur]
Institut Laue-Langevin [ILL]
Jimenez-Ruiz, Monica [Auteur]
Institut Laue-Langevin [ILL]
Hamoudi, Mounira [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Advanced Drug Delivery Systems (ADDS) - U1008
Affouard, Frédéric [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Unité Matériaux et Transformations (UMET) - UMR 8207

Journal title :

Molecular Pharmaceutics

Abbreviated title :

Mol. Pharmaceutics

Volume number :

17

Pages :

1-9

Publisher :

American Chemical Society (ACS)

Publication date :

2020-01-06

English keyword(s) :

mutarotation
amorphization
milling
quenching melt
spray-drying
freeze-drying
molecular dynamics simulation
MDSC
NMR

HAL domain(s) :

Physique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
Physique [physics]/Matière Condensée [cond-mat]/Systèmes désordonnés et réseaux de neurones [cond-mat.dis-nn]

English abstract : [en]

The influence of the amorphization technique on the physicochemical properties of amorphous lactulose was investigated. Four different amorphization techniques were used: quenching of the melt, milling, spray-drying, and ...
Show more >The influence of the amorphization technique on the physicochemical properties of amorphous lactulose was investigated. Four different amorphization techniques were used: quenching of the melt, milling, spray-drying, and freeze-drying, and amorphous samples were analyzed by differential scanning calorimetry, NMR spectroscopy, and powder X-ray diffraction analysis. Special attention was paid to the tautomeric composition and to the glass transition of amorphized materials. It was found that the tautomeric composition of the starting physical state (crystal, liquid, or solution) is preserved during the amorphization process and has a strong repercussion on the glass transition of the material. The correlation between these two properties as well as the plasticizing effect of the different tautomers was clarified by molecular dynamics simulations.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Non spécifiée

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008
• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2019-11-04T10:33:22Z
2019-11-04T10:47:21Z
2019-11-07T14:16:28Z
2020-02-11T13:54:28Z
2020-11-17T09:16:10Z
2020-12-15T14:24:57Z
2021-03-03T14:33:02Z