Title :

Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac

Author(s) :

Latreche, Mansour [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
willart, Jean-François [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Paccou, Laurent [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Guinet, Yannick [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Hedoux, Alain [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]

Journal title :

International Journal of Pharmaceutics

Abbreviated title :

International Journal of Pharmaceutics

Volume number :

567

Pages :

118476

Publisher :

Elsevier BV

Publication date :

2019-08

ISSN :

0378-5173

HAL domain(s) :

Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]

English abstract : [en]

The polymorphism of sulindac was investigated by Raman investigations, mainly in the low-wavenumber region in order to analyze the influence of the amorphization method on recrystallization and crystalline form stability. ...
Show more >The polymorphism of sulindac was investigated by Raman investigations, mainly in the low-wavenumber region in order to analyze the influence of the amorphization method on recrystallization and crystalline form stability. By devitrification of the quenched liquid, it was found that the undercooled liquid crystallizes into Form I, and a polymorphic transformation by cooling Form I toward Form IV, was clearly revealed. The low-wavenumber spectra of polymorphic forms are direct fingerprints of crystals, indicating a degree of disorder of Form IV intermediate between those of the ordered Form II (commercial form) and the relatively disordered Form I. This study has shown the enantiotropic relationship between Forms I and IV and that both the temperature of crystallization and the physical stability of Form I prepared is dependent on the technique used for preparing amorphous sulindac.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Research team(s) :

Matériaux Moléculaires et Thérapeutiques

Submission date :

2019-11-21T12:46:18Z
2020-07-18T13:29:40Z
2020-11-16T08:42:57Z
2020-11-16T08:48:42Z
2020-11-25T15:15:13Z