Titre :

Polymorphism versus devitrification mechanism: Low-wavenumber Raman investigations in sulindac

Auteur(s) :

Latreche, Mansour [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
willart, Jean-François [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Paccou, Laurent [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Guinet, Yannick [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]
Hedoux, Alain [Auteur]
Unité Matériaux et Transformations - UMR 8207 [UMET]

Titre de la revue :

International Journal of Pharmaceutics

Nom court de la revue :

International Journal of Pharmaceutics

Numéro :

567

Pagination :

118476

Éditeur :

Elsevier BV

Date de publication :

2019-08

ISSN :

0378-5173

Discipline(s) HAL :

Physique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]

Résumé en anglais : [en]

The polymorphism of sulindac was investigated by Raman investigations, mainly in the low-wavenumber region in order to analyze the influence of the amorphization method on recrystallization and crystalline form stability. ...
Lire la suite >The polymorphism of sulindac was investigated by Raman investigations, mainly in the low-wavenumber region in order to analyze the influence of the amorphization method on recrystallization and crystalline form stability. By devitrification of the quenched liquid, it was found that the undercooled liquid crystallizes into Form I, and a polymorphic transformation by cooling Form I toward Form IV, was clearly revealed. The low-wavenumber spectra of polymorphic forms are direct fingerprints of crystals, indicating a degree of disorder of Form IV intermediate between those of the ordered Form II (commercial form) and the relatively disordered Form I. This study has shown the enantiotropic relationship between Forms I and IV and that both the temperature of crystallization and the physical stability of Form I prepared is dependent on the technique used for preparing amorphous sulindac.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

• Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Matériaux Moléculaires et Thérapeutiques

Date de dépôt :

2019-11-21T12:46:18Z
2020-07-18T13:29:40Z
2020-11-16T08:42:57Z
2020-11-16T08:48:42Z
2020-11-25T15:15:13Z