Role of cerebral microbleeds for intracerebral haemorrhage and dementia

Moulin, Solene; Cordonnier, Charlotte

Document type :

Article dans une revue scientifique: Article de synthèse/Review paper

DOI :

10.1007/s11910-019-0969-0

PMID :

31218453

Permalink :

http://hdl.handle.net/20.500.12210/15842

Title :

Role of cerebral microbleeds for intracerebral haemorrhage and dementia

Author(s) :

Moulin, Solene [Auteur]
Cordonnier, Charlotte [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171

Journal title :

Current Neurology and Neuroscience Reports

Abbreviated title :

Curr Neurol Neurosci Rep

Volume number :

Pages :

Publication date :

2019-06-19

ISSN :

1534-6293

English keyword(s) :

Ischaemic stroke
Cerebral microbleeds
Cognitive impairment
Dementia
Intracerebral haemorrhage

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Cerebral microbleeds (CMB)-small round or ovoid lesions detected in hyposignal on blood-sensitive MRI sequences-are promising radiological biomarkers of cerebral small vessel disease. Their relations with ischaemic ...
Show more >OBJECTIVE: Cerebral microbleeds (CMB)-small round or ovoid lesions detected in hyposignal on blood-sensitive MRI sequences-are promising radiological biomarkers of cerebral small vessel disease. Their relations with ischaemic or haemorragic stroke and their potential contribution to dementia have been extensively addressed. This article reviews recent research on the clinical significance of CMB that remains to be determined. RESULTS: The presence, burden and location of CMB allow to obtain a more accurate estimate of intracerebral haemorrhage and ischaemic stroke risk. Most studies evaluating the association between CMB and dementia are hampered by methodological limitations and show conflicting results. CMB mainly reflect the severity of the underlying small vessel disease and should not be interpreted independently of the others neuroimaging biomarkers or the clinical setting. Future large prospective longitudinal studies and randomized controlled trials in various settings are required to determine whether specific therapies are beneficial in case of incidental findings.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:01:42Z

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