Title :

Vascular targeted photodynamic therapy with tookad (r) soluble (wst11) in localized prostate cancer: efficiency of automatic pre-treatment planning

Author(s) :

Betrouni, Nacim [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Boukris, S. [Auteur]
Benzaghou, F. [Auteur]

Journal title :

Lasers in medical science

Abbreviated title :

Lasers Med. Sci.

Volume number :

32

Pages :

1301-1307

Publication date :

2017-08-01

ISSN :

0268-8921

English keyword(s) :

Photodynamic therapy
Image guided procedure
Prostate cancer
Treatment planning

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Vascular targeted photodynamic therapy (VTP) with WST11 is a novel non-thermal focal treatment for localized prostate cancer that has shown favorable and early efficacy results in previously published studies. In this work, ...
Show more >Vascular targeted photodynamic therapy (VTP) with WST11 is a novel non-thermal focal treatment for localized prostate cancer that has shown favorable and early efficacy results in previously published studies. In this work, we investigate the efficiency of automatic dosimetric treatment planning. An action model established in a previous study was used in an image-guided optimization scheme to define the personalized optimal light dose for each patient. The calculated light dose is expressed as the number of optical cylindrical fibers to be used, their positions according to an external insertion grid, and the lengths of their diffuser parts. Evaluation of the method was carried out on data collected from 17 patients enrolled in two multi-centric clinical trials. The protocol consisted of comparing the method-simulated necrosis to the result observed on day 7 MR enhanced images. The method performances showed that the final result can be estimated with an accuracy of 10%, corresponding to a margin of 3 mm. In addition, this process was compatible with clinical conditions in terms of calculation times. The overall process took less than 10 min. Different aspects of the VTP procedure were already defined and optimized. Personalized treatment planning definition remained as an issue needing further investigation. The method proposed herein completes the standardization of VTP and opens new pathways for the clinical development of the technique.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Autres travaux scientifiques

Submission date :

2019-11-27T13:01:55Z