Incidence of hospital admissions due to adverse drug reactions in france: the emir study

Benard-Laribiere, Anne; Miremont-Salame, Ghada; Perault-Pochat, Marie-Christine; Noize, Pernelle; Haramburu, Françoise

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1111/fcp.12088

PMID :

24990220

Permalink :

http://hdl.handle.net/20.500.12210/15940

Title :

Incidence of hospital admissions due to adverse drug reactions in france: the emir study

Author(s) :

Benard-Laribiere, Anne [Auteur]
Miremont-Salame, Ghada [Auteur]
Perault-Pochat, Marie-Christine [Auteur]
Noize, Pernelle [Auteur]
Haramburu, Françoise [Auteur]

Journal title :

Fundamental & clinical pharmacology

Abbreviated title :

Fundam Clin Pharmacol

Volume number :

Pages :

106-11

Publication date :

2015-02-01

ISSN :

1472-8206

English keyword(s) :

adverse drug reactions
pharmacovigilance
prospective studies
incidence
hospitalization

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected ...
Show more >To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients admitted during a 2-week period were included. An ADR-related hospitalization case was defined as a hospital admission because of an ADR, and an independent committee reviewed and validated all potential cases. Preventability was assessed using the French ADR preventability scale. Data were extrapolated to the population of France. Among 2692 admissions, 97 were related to an ADR (incidence 3.6%, 95% confidence interval, CI [2.8-4.4]). Patients admitted for an ADR were significantly older than those admitted for other reasons (P < 0.001). A third (32.0%) of ADR-related hospitalizations were 'preventable', 16.5% 'potentially preventable'. Drug interactions accounted for 29.9% of ADR-related hospitalizations. The most frequent causes of ADR-related hospitalizations were vascular disorders (20.6%), mainly bleeding complications, central nervous system disorders (11.3%), gastrointestinal disorders, and general disorders (9.3%). Antithrombotic and antineoplastic agents were the most frequently involved (12.6% each), followed by diuretics and analgesics (9.0% each). Vitamin-K-antagonists (VKAs) were the most common drugs associated with admission. The estimated annual number of ADR-related hospitalizations in France was 143 915 (95% CI [112 063-175 766]). ADRs were a significant cause of hospital admission in 2006-2007, in particular those due to VKAs. As new oral anticoagulants (NOACs) have been marketed, more attention needs to be paid to ensure a safe use of antithrombotic agents.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:02:34Z

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