[gastric acid rebound after a proton pump inhibitor: narrative review of literature]

Rochoy, Michael; Dubois, Sébastien; Glantenet, Raymond; Gautier, Sophie; Lambert, Marc

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.therap.2017.08.005

PMID :

29195714

Permalink :

http://hdl.handle.net/20.500.12210/15985

Title :

[gastric acid rebound after a proton pump inhibitor: narrative review of literature]

Author(s) :

Rochoy, Michael [Auteur]
Dubois, Sébastien [Auteur]
Glantenet, Raymond [Auteur]
Gautier, Sophie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Lambert, Marc [Auteur]

Lille Inflammation Research International Center - U 995 [LIRIC]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Therapie

Abbreviated title :

Therapie

Publication date :

2017-10-26

ISSN :

0040-5957

English keyword(s) :

Rebound effect
Literature review
Proton pump inhibitors

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Since the introduction of the first proton pump inhibitor (PPI) 20 years ago, studies have examined the presence of a rebound effect when this treatment is discontinued. These studies are heterogeneous and ...
Show more >BACKGROUND: Since the introduction of the first proton pump inhibitor (PPI) 20 years ago, studies have examined the presence of a rebound effect when this treatment is discontinued. These studies are heterogeneous and contradictory: the last literature review on the rebound in gastric acidity dates from 2006 and did not allow to conclude on the subject. Our objective was to carry out an up-to-date literature review on the existence and characteristics of this gastric acid rebound at the end of PPIs. METHODS: We conducted a review of the literature on the gastric acid rebound, without excluding the design of the studies. The Medline® RESULTS: Of the 131 publications identified, 10 were selected. The design of the studies was very heterogeneous. Five studies concluded a rebound effect. Studies with a treatment duration of less than 4 weeks did not demonstrate a rebound effect. The colonization with Helicobacter pylori masked the appearance of the rebound. CONCLUSIONS: Daily PPI exposure for more than 4 weeks is likely to trigger a rebound of acid hypersecretion about 15 days after discontinuation, and lasting from a few days to several weeks depending on the duration of the exposure.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2019-11-27T13:03:06Z

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