Early occurrence of inspiratory muscle weakness in parkinson''s disease

Baille, Guillaume; Perez, Thierry; Devos, David; Deken, Valerie; Defebvre, Luc; Moreau, caroline

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1371/journal.pone.0190400

PMID :

29329328

Permalink :

http://hdl.handle.net/20.500.12210/16035

Title :

Early occurrence of inspiratory muscle weakness in parkinson''s disease

Author(s) :

Baille, Guillaume [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Perez, Thierry [Auteur]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Devos, David [Auteur]

451074|||Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV] (OLD)
Deken, Valerie [Auteur]

Service de Biostatistiques [CHRU Lille]
Defebvre, Luc [Auteur]

451074|||Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV] (OLD)
Moreau, caroline [Auteur]

451074|||Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV] (OLD)

Journal title :

PLoS One

Abbreviated title :

PLoS One

Volume number :

Pages :

e0190400

Publication date :

2018-01-12

ISSN :

1932-6203

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

In Parkinson's disease (PD), respiratory insufficiency (including functional and muscle disorders) can impact dysarthria and swallowing. Most studies of this topic have been performed retrospectively in populations of ...
Show more >In Parkinson's disease (PD), respiratory insufficiency (including functional and muscle disorders) can impact dysarthria and swallowing. Most studies of this topic have been performed retrospectively in populations of patients with advanced PD. The objective of the present study was to characterize lung function (under off-drug conditions) in early-stage PD patients at baseline and then again two years later. Forty-one early-stage PD patients (mean ± SD age: 61.7 ± 7.7; mean ± SD disease duration: 1.9 ± 1.7 years) were prospectively enrolled and compared with 36 age-matched healthy controls. Neurological evaluations and pulmonary function testing were performed in the off-drug condition at the inclusion visit and then two years later. Pulmonary function testing did not reveal any restrictive or obstructive disorders; at baseline, inspiratory muscle weakness was the only abnormality observed in the PD group (in 53.7% of the patients, vs. 25% in controls; p = 0.0105). The PD patients had a lower mean maximal inspiratory mouth pressure than controls and a lower sniff nasal inspiratory pressure. Two years after the initiation of chronic treatment with antiparkinsonian medications, the maximal inspiratory mouth pressure and the sniff nasal inspiratory pressure tended to be higher. Lastly, overall motor outcomes were not significantly worse in patients with inspiratory muscle weakness than in patients without inspiratory muscle weakness. Inspiratory muscle weakness seems to be common in patients with early-stage PD, and was seen to be stable over a two-year period. Additional long-term follow-up studies are required to specify the impact of this new feature of PD.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2019-11-27T13:04:16Z
2024-03-27T10:27:45Z

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States

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2	20.500.12210/16035*	2024-03-27T10:19:41Z
1	20.500.12210/16035.1	2019-11-27T13:04:16Z

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Early occurrence of inspiratory muscle ...

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