Early occurrence of inspiratory muscle weakness in parkinson''s disease

Baille, Guillaume; Perez, Thierry; Devos, David; Deken, Valerie; Defebvre, Luc; Moreau, caroline

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1371/journal.pone.0190400

PMID :

29329328

URL permanente :

http://hdl.handle.net/20.500.12210/16035

Titre :

Early occurrence of inspiratory muscle weakness in parkinson''s disease

Auteur(s) :

Baille, Guillaume [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Perez, Thierry [Auteur]

Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Devos, David [Auteur]

451074|||Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV] (OLD)
Deken, Valerie [Auteur]

Service de Biostatistiques [CHRU Lille]
Defebvre, Luc [Auteur]

451074|||Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV] (OLD)
Moreau, caroline [Auteur]

451074|||Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV] (OLD)

Titre de la revue :

PLoS One

Nom court de la revue :

PLoS One

Numéro :

Pagination :

e0190400

Date de publication :

2018-01-12

ISSN :

1932-6203

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

In Parkinson's disease (PD), respiratory insufficiency (including functional and muscle disorders) can impact dysarthria and swallowing. Most studies of this topic have been performed retrospectively in populations of ...
Lire la suite >In Parkinson's disease (PD), respiratory insufficiency (including functional and muscle disorders) can impact dysarthria and swallowing. Most studies of this topic have been performed retrospectively in populations of patients with advanced PD. The objective of the present study was to characterize lung function (under off-drug conditions) in early-stage PD patients at baseline and then again two years later. Forty-one early-stage PD patients (mean ± SD age: 61.7 ± 7.7; mean ± SD disease duration: 1.9 ± 1.7 years) were prospectively enrolled and compared with 36 age-matched healthy controls. Neurological evaluations and pulmonary function testing were performed in the off-drug condition at the inclusion visit and then two years later. Pulmonary function testing did not reveal any restrictive or obstructive disorders; at baseline, inspiratory muscle weakness was the only abnormality observed in the PD group (in 53.7% of the patients, vs. 25% in controls; p = 0.0105). The PD patients had a lower mean maximal inspiratory mouth pressure than controls and a lower sniff nasal inspiratory pressure. Two years after the initiation of chronic treatment with antiparkinsonian medications, the maximal inspiratory mouth pressure and the sniff nasal inspiratory pressure tended to be higher. Lastly, overall motor outcomes were not significantly worse in patients with inspiratory muscle weakness than in patients without inspiratory muscle weakness. Inspiratory muscle weakness seems to be common in patients with early-stage PD, and was seen to be stable over a two-year period. Additional long-term follow-up studies are required to specify the impact of this new feature of PD.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Date de dépôt :

2019-11-27T13:04:16Z
2024-03-27T10:27:45Z

Fichiers

file.pdf
Non spécifié
Accès libre
Accéder au document

Ce document est diffusé sous licence Attribution-NonCommercial-NoDerivs 3.0 United States

Numéro de version	Lien	Date de modification
2	20.500.12210/16035*	2024-03-27T10:19:41Z
1	20.500.12210/16035.1	2019-11-27T13:04:16Z

Early occurrence of inspiratory muscle ...

BibTeX

CSV

Excel

RIS

Fichiers

Historique des modifications

Early occurrence of inspiratory muscle ... BibTeX CSV Excel RIS

Fichiers

Historique des modifications

Early occurrence of inspiratory muscle ...

BibTeX

CSV

Excel

RIS