Titre :

Brain imaging of locomotion in neurological conditions

Auteur(s) :

Allali, Gilles [Auteur]
Université de Genève = University of Geneva [UNIGE]
Blumen, Helena M. [Auteur]
Albert Einstein College of Medicine [New York]
Devanne, Hervé [Auteur]
Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS]
Pirondini, Elvira [Auteur]
Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne] [CHUV]
Delval, Arnaud [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Van De Ville, Dimitri [Auteur]
Université de Genève = University of Geneva [UNIGE]

Titre de la revue :

Neurophysiologie clinique = Clinical neurophysiology

Nom court de la revue :

Neurophysiol Clin

Numéro :

48

Pagination :

337-359

Éditeur :

Elsevier

Date de publication :

2018-12-01

ISSN :

1769-7131

Mot(s)-clé(s) en anglais :

Stroke
Parkinson''s disease
Gait disorders
Neuroimaging
Neurological conditions
Methods
Review
Dementia
Multiple Sclerosis

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Impaired locomotion is a frequent and major source of disability in patients with neurological conditions. Different neuroimaging methods have been used to understand the brain substrates of locomotion in various neurological ...
Lire la suite >Impaired locomotion is a frequent and major source of disability in patients with neurological conditions. Different neuroimaging methods have been used to understand the brain substrates of locomotion in various neurological diseases (mainly in Parkinson's disease) during actual walking, and while resting (using mental imagery of gait, or brain-behavior correlation analyses). These studies, using structural (i.e., MRI) or functional (i.e., functional MRI or functional near infra-red spectroscopy) brain imaging, electrophysiology (i.e., EEG), non-invasive brain stimulation (i.e., transcranial magnetic stimulation, or transcranial direct current stimulation) or molecular imaging methods (i.e., PET, or SPECT) reveal extended brain networks involving both grey and white matters in key cortical (i.e., prefrontal cortex) and subcortical (basal ganglia and cerebellum) regions associated with locomotion. However, the specific roles of the various pathophysiological mechanisms encountered in each neurological condition on the phenotype of gait disorders still remains unclear. After reviewing the results of individual brain imaging techniques across the common neurological conditions, such as Parkinson's disease, dementia, stroke, or multiple sclerosis, we will discuss how the development of new imaging techniques and computational analyses that integrate multivariate correlations in "large enough datasets" might help to understand how individual pathophysiological mechanisms express clinically as an abnormal gait. Finally, we will explore how these new analytic methods could drive our rehabilitative strategies.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Univ. Artois
Univ. Littoral Côte d’Opale
Université de Lille

Collections :

• Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369

Date de dépôt :

2019-11-27T13:04:28Z
2024-02-07T10:09:46Z