Prognostic factors for cognitive decline after intracerebral hemorrhage

Benedictus, Marije R.; Hochart, Anais; Rossi, Costanza; Boulouis, Gregoire; Henon, Hilde; Van Der Flier, Wiesje M.; Cordonnier, Charlotte

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1161/STROKEAHA.115.010200

PMID :

26272386

Permalink :

http://hdl.handle.net/20.500.12210/16062

Title :

Prognostic factors for cognitive decline after intracerebral hemorrhage

Author(s) :

Benedictus, Marije R. [Auteur]
Hochart, Anais [Auteur]
Rossi, Costanza [Auteur]
Boulouis, Gregoire [Auteur]
Henon, Hilde [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Van Der Flier, Wiesje M. [Auteur]
Cordonnier, Charlotte [Auteur]

Journal title :

Stroke

Abbreviated title :

Stroke

Volume number :

Pages :

2773-2778

Publication date :

2015-10-01

ISSN :

0039-2499

English keyword(s) :

dementia
ischemic attack
transient
mild cognitive impairment
stroke
cerebral hemorrhage

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: Stroke and dementia are closely related, but no prospective study ever focused on poststroke cognitive decline in patients with intracerebral hemorrhage (ICH). We aimed to determine prognostic factors for cognitive ...
Show more >OBJECTIVE: Stroke and dementia are closely related, but no prospective study ever focused on poststroke cognitive decline in patients with intracerebral hemorrhage (ICH). We aimed to determine prognostic factors for cognitive decline in patients with ICH. METHODS: We prospectively included 167 consecutive ICH survivors without preexisting dementia from the Prognosis of Intra-Cerebral Hemorrhage (PITCH) cohort. Median follow-up was 4 years (interquartile range, 2.3-5.4). We explored factors associated with cognitive decline using linear mixed models. Cognitive decline was determined based on repeated mini-mental state examination. We investigated each prognostic factor separately in univariate models. Next, we constructed clinical and radiological multivariable models. In a sensitivity analysis, we excluded patients with preexisting cognitive impairment. RESULTS: Median age was 64 (interquartile range, 53-75) years, 69 (41%) patients were women, and median mini-mental state examination at 6 months was 27 (interquartile range, 23-29). Overall, 37% of the patients declined during follow-up. Factors associated with cognitive decline in univariate analyses were previous stroke or transient ischemic attack, preexisting cognitive impairment, microbleed presence, severity of white matter hyperintensities, and severity of cortical atrophy. In multivariable analyses, previous stroke or transient ischemic attack (β [SE], -0.55 [0.23]; P<0.05), preexisting cognitive impairment (β [SE], -0.56 [0.25]; P<0.01), and severity of cortical atrophy (β [SE], -0.50 [0.19]; P<0.01) remained independent prognostic factors. In patients without preexisting cognitive impairment (n=139), severity of cortical atrophy (β [SE], -0.38 [0.17]; P<0.05) was the only prognostic factor for future cognitive decline. CONCLUSIONS: Prognostic factors for cognitive decline after ICH are already present when ICH occurs, suggesting a process of ongoing cognitive impairment instead of new-onset decline induced by the ICH itself.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:04:48Z

Prognostic factors for cognitive decline ... BibTeX CSV Excel RIS

Prognostic factors for cognitive decline ...

BibTeX

CSV

Excel

RIS