Prognostic factors for cognitive decline after intracerebral hemorrhage

Benedictus, Marije R.; Hochart, Anais; Rossi, Costanza; Boulouis, Gregoire; Henon, Hilde; Van Der Flier, Wiesje M.; Cordonnier, Charlotte

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1161/STROKEAHA.115.010200

PMID :

26272386

URL permanente :

http://hdl.handle.net/20.500.12210/16062

Titre :

Prognostic factors for cognitive decline after intracerebral hemorrhage

Auteur(s) :

Benedictus, Marije R. [Auteur]
Hochart, Anais [Auteur]
Rossi, Costanza [Auteur]
Boulouis, Gregoire [Auteur]
Henon, Hilde [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Van Der Flier, Wiesje M. [Auteur]
Cordonnier, Charlotte [Auteur]

Titre de la revue :

Stroke

Nom court de la revue :

Stroke

Numéro :

Pagination :

2773-2778

Date de publication :

2015-10-01

ISSN :

0039-2499

Mot(s)-clé(s) en anglais :

dementia
ischemic attack
transient
mild cognitive impairment
stroke
cerebral hemorrhage

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

OBJECTIVE: Stroke and dementia are closely related, but no prospective study ever focused on poststroke cognitive decline in patients with intracerebral hemorrhage (ICH). We aimed to determine prognostic factors for cognitive ...
Lire la suite >OBJECTIVE: Stroke and dementia are closely related, but no prospective study ever focused on poststroke cognitive decline in patients with intracerebral hemorrhage (ICH). We aimed to determine prognostic factors for cognitive decline in patients with ICH. METHODS: We prospectively included 167 consecutive ICH survivors without preexisting dementia from the Prognosis of Intra-Cerebral Hemorrhage (PITCH) cohort. Median follow-up was 4 years (interquartile range, 2.3-5.4). We explored factors associated with cognitive decline using linear mixed models. Cognitive decline was determined based on repeated mini-mental state examination. We investigated each prognostic factor separately in univariate models. Next, we constructed clinical and radiological multivariable models. In a sensitivity analysis, we excluded patients with preexisting cognitive impairment. RESULTS: Median age was 64 (interquartile range, 53-75) years, 69 (41%) patients were women, and median mini-mental state examination at 6 months was 27 (interquartile range, 23-29). Overall, 37% of the patients declined during follow-up. Factors associated with cognitive decline in univariate analyses were previous stroke or transient ischemic attack, preexisting cognitive impairment, microbleed presence, severity of white matter hyperintensities, and severity of cortical atrophy. In multivariable analyses, previous stroke or transient ischemic attack (β [SE], -0.55 [0.23]; P<0.05), preexisting cognitive impairment (β [SE], -0.56 [0.25]; P<0.01), and severity of cortical atrophy (β [SE], -0.50 [0.19]; P<0.01) remained independent prognostic factors. In patients without preexisting cognitive impairment (n=139), severity of cortical atrophy (β [SE], -0.38 [0.17]; P<0.05) was the only prognostic factor for future cognitive decline. CONCLUSIONS: Prognostic factors for cognitive decline after ICH are already present when ICH occurs, suggesting a process of ongoing cognitive impairment instead of new-onset decline induced by the ICH itself.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Équipe(s) de recherche :

Troubles cognitifs dégénératifs et vasculaires

Date de dépôt :

2019-11-27T13:04:48Z

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