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Cortical superficial siderosis: a prospective ...
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Document type :
Article dans une revue scientifique: Article original
DOI :
10.1212/WNL.0000000000005778
PMID :
29884737
Permalink :
http://hdl.handle.net/20.500.12210/16153
Title :
Cortical superficial siderosis: a prospective observational cohort study
Author(s) :
Moulin, Solene [Auteur]
Casolla, Barbara [Auteur]
Kuchcinski, Gregory [Auteur] refId
Boulouis, Gregoire [Auteur]
Rossi, Costanza [Auteur]
Henon, Hilde [Auteur] refId
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
LEYS, Didier [Auteur] refId
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Cordonnier, Charlotte [Auteur] refId
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Journal title :
Neurology
Abbreviated title :
Neurology
Publication date :
2018-06-08
ISSN :
1526-632X
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
To determine the prevalence of cortical superficial siderosis (cSS), its clinical and neuroimaging associated markers, and its influence on the risk of recurrent intracerebral hemorrhage (ICH) in a prospective observational ...
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To determine the prevalence of cortical superficial siderosis (cSS), its clinical and neuroimaging associated markers, and its influence on the risk of recurrent intracerebral hemorrhage (ICH) in a prospective observational ICH cohort. We investigated clinical and radiologic markers associated with cSS using multivariable analysis. In survival analyses, we used Cox models to identify predictors of recurrent ICH after adjusting for potential confounders. Of the 258 patients included in the study, 49 (19%; 95% confidence interval [CI] 14%-24%) had cSS at baseline. Clinical factors independently associated with the presence of cSS were increasing age (odds ratio [OR] 1.03 per 1-year increase, 95% CI 1.001-1.06, ppppppp In a prospective observational cohort of spontaneous ICH, clinical and radiologic markers associated with cSS suggest the implication of underlying cerebral amyloid angiopathy. Disseminated cSS may become a key prognostic neuroimaging marker of recurrent ICH that could be monitored in future clinical trials dedicated to patients with ICH.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
Collections :
  • Lille Neurosciences & Cognition (LilNCog) - U 1172
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T13:34:07Z
Université de Lille

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