Title :

Donepezil increases contrast sensitivity for the detection of objects in scenes

Author(s) :

Boucart, Muriel [Auteur]
Sciences Cognitives et Sciences Affectives (SCALab) - UMR 9193
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Bubicco, Giovanna [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Szaffarczyk, Sébastien [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Defoort, Sabine [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Ponchel, Amélie [Auteur]
Waucquier, Nawal [Auteur]
Deplanque, Dominique [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Deguil, Julie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Bordet, Regis [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]

Journal title :

Behavioural brain research

Abbreviated title :

Behav. Brain Res.

Volume number :

292

Pages :

443-447

Publication date :

2015-10-01

ISSN :

0166-4328

English keyword(s) :

Acetylcholine
Donepezil
Alzheimer
Scopolamine
Contrast perception
Mesh:Indans/administration & dosage*
Mesh:Humans
Mesh:Contrast Sensitivity/drug effects*
Mesh:Cholinesterase Inhibitors/administration & dosage*
Mesh:Cholinergic Antagonists/administration & dosage
Mesh:Signal Detection
Mesh:Psychological/drug effects*
Mesh:Adult
Mesh:Young Adult
Mesh:Scopolamine Hydrobromide/administration & dosage
Mesh:Reaction Time/drug effects
Mesh:Piperidines/administration & dosage*
Mesh:Pattern Recognition
Mesh:Visual/drug effects
Mesh:Male

HAL domain(s) :

Sciences du Vivant [q-bio]
Sciences cognitives

English abstract : [en]

We assessed the effects of donepezil, a drug that stimulates cholinergic transmission, and scopolamine, an antagonist of cholinergic transmission, on contrast sensitivity. 30 young male participants were tested under three ...
Show more >We assessed the effects of donepezil, a drug that stimulates cholinergic transmission, and scopolamine, an antagonist of cholinergic transmission, on contrast sensitivity. 30 young male participants were tested under three treatment conditions: placebo, donepezil, and scopolamine in a random order. Pairs of photographs varying in contrast were displayed left and right of fixation for 50 ms. Participants were asked to locate the scene containing an animal. Accuracy was better under donepezil than under scopolamine, particularly for signals of high intensity (at higher levels of contrast). A control experiment showed that the lower performance under scopolamine did not result from the mydriasis induced by scopolamine. The results suggest that cholinergic stimulation, through donepezil, facilitates signal detection in agreement with studies on animals showing that the pharmacological activation of cholinergic receptors controls the gain in the relationship between the stimulus contrast (intensity of the visual input) and visual response. As Alzheimer disease is associated to depletion in acetylcholine, and there is evidence of deficits in contrast sensitivity in Alzheimer, it might be interesting to integrate such rapid and sensitive visual tasks in the biomarkers at early stage of drug development.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:34:30Z
2020-01-21T15:30:11Z