Hypothermia during carotid endarterectomy: a safety study

Candela, Serena; Dito, Raffaele; Casolla, Barbara; Silvestri, Emanuele; Sette, Giuliano; Filippi, Federico; Taurino, Maurizio; Brancadoro, Domitilla; Orzi, Francesco

Document type :

Article dans une revue scientifique: Article original

DOI :

10.1371/journal.pone.0152658

PMID :

27058874

Permalink :

http://hdl.handle.net/20.500.12210/16193

Title :

Hypothermia during carotid endarterectomy: a safety study

Author(s) :

Candela, Serena [Auteur]
Dito, Raffaele [Auteur]
Casolla, Barbara [Auteur]
Silvestri, Emanuele [Auteur]
Sette, Giuliano [Auteur]
Filippi, Federico [Auteur]
Taurino, Maurizio [Auteur]
Brancadoro, Domitilla [Auteur]
Orzi, Francesco [Auteur]

Journal title :

PLoS One

Abbreviated title :

PLoS One

Volume number :

Publication date :

2016-04-08

ISSN :

1932-6203

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: CEA is associated with peri-operative risk of brain ischemia, due both to emboli production caused by manipulation of the plaque and to potentially noxious reduction of cerebral blood flow by carotid clamping. ...
Show more >BACKGROUND: CEA is associated with peri-operative risk of brain ischemia, due both to emboli production caused by manipulation of the plaque and to potentially noxious reduction of cerebral blood flow by carotid clamping. Mild hypothermia (34-35°C) is probably the most effective approach to protect brain from ischemic insult. It is therefore a substantial hypothesis that hypothermia lowers the risk of ischemic brain damage potentially associated with CEA. Purpose of the study is to test whether systemic endovascular cooling to a target of 34.5-35°C, initiated before and maintained during CEA, is feasible and safe. METHODS: The study was carried out in 7 consecutive patients referred to the Vascular Surgery Unit and judged eligible for CEA. Cooling was initiated 60-90 min before CEA, by endovascular approach (Zoll system). The target temperature was maintained during CEA, followed by passive, controlled rewarming (0.4°C/h). The whole procedure was carried out under anesthesia. RESULTS: All the patients enrolled had no adverse events. Two patients exhibited a transient bradycardia (heart rate 30 beats/min). There were no significant differences in the clinical status, laboratory and physiological data measured before and after CEA. CONCLUSIONS: Systemic cooling to 34.5-35.0°C, initiated before and maintained during carotid clamping, is feasible and safe. BACKGROUND: ClinicalTrials.gov NCT02629653.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:34:40Z

Hypothermia during carotid endarterectomy: ... BibTeX CSV Excel RIS

Hypothermia during carotid endarterectomy: ...

BibTeX

CSV

Excel

RIS