Hypothermia during carotid endarterectomy: ...
Type de document :
Article dans une revue scientifique: Article original
PMID :
URL permanente :
Titre :
Hypothermia during carotid endarterectomy: a safety study
Auteur(s) :
Candela, Serena [Auteur]
Dito, Raffaele [Auteur]
Casolla, Barbara [Auteur]
Silvestri, Emanuele [Auteur]
Sette, Giuliano [Auteur]
Filippi, Federico [Auteur]
Taurino, Maurizio [Auteur]
Brancadoro, Domitilla [Auteur]
Orzi, Francesco [Auteur]
Dito, Raffaele [Auteur]
Casolla, Barbara [Auteur]
Silvestri, Emanuele [Auteur]
Sette, Giuliano [Auteur]
Filippi, Federico [Auteur]
Taurino, Maurizio [Auteur]
Brancadoro, Domitilla [Auteur]
Orzi, Francesco [Auteur]
Titre de la revue :
PLoS One
Nom court de la revue :
PLoS One
Numéro :
11
Date de publication :
2016-04-08
ISSN :
1932-6203
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
BACKGROUND: CEA is associated with peri-operative risk of brain ischemia, due both to emboli production caused by manipulation of the plaque and to potentially noxious reduction of cerebral blood flow by carotid clamping. ...
Lire la suite >BACKGROUND: CEA is associated with peri-operative risk of brain ischemia, due both to emboli production caused by manipulation of the plaque and to potentially noxious reduction of cerebral blood flow by carotid clamping. Mild hypothermia (34-35°C) is probably the most effective approach to protect brain from ischemic insult. It is therefore a substantial hypothesis that hypothermia lowers the risk of ischemic brain damage potentially associated with CEA. Purpose of the study is to test whether systemic endovascular cooling to a target of 34.5-35°C, initiated before and maintained during CEA, is feasible and safe. METHODS: The study was carried out in 7 consecutive patients referred to the Vascular Surgery Unit and judged eligible for CEA. Cooling was initiated 60-90 min before CEA, by endovascular approach (Zoll system). The target temperature was maintained during CEA, followed by passive, controlled rewarming (0.4°C/h). The whole procedure was carried out under anesthesia. RESULTS: All the patients enrolled had no adverse events. Two patients exhibited a transient bradycardia (heart rate 30 beats/min). There were no significant differences in the clinical status, laboratory and physiological data measured before and after CEA. CONCLUSIONS: Systemic cooling to 34.5-35.0°C, initiated before and maintained during carotid clamping, is feasible and safe. BACKGROUND: ClinicalTrials.gov NCT02629653.Lire moins >
Lire la suite >BACKGROUND: CEA is associated with peri-operative risk of brain ischemia, due both to emboli production caused by manipulation of the plaque and to potentially noxious reduction of cerebral blood flow by carotid clamping. Mild hypothermia (34-35°C) is probably the most effective approach to protect brain from ischemic insult. It is therefore a substantial hypothesis that hypothermia lowers the risk of ischemic brain damage potentially associated with CEA. Purpose of the study is to test whether systemic endovascular cooling to a target of 34.5-35°C, initiated before and maintained during CEA, is feasible and safe. METHODS: The study was carried out in 7 consecutive patients referred to the Vascular Surgery Unit and judged eligible for CEA. Cooling was initiated 60-90 min before CEA, by endovascular approach (Zoll system). The target temperature was maintained during CEA, followed by passive, controlled rewarming (0.4°C/h). The whole procedure was carried out under anesthesia. RESULTS: All the patients enrolled had no adverse events. Two patients exhibited a transient bradycardia (heart rate 30 beats/min). There were no significant differences in the clinical status, laboratory and physiological data measured before and after CEA. CONCLUSIONS: Systemic cooling to 34.5-35.0°C, initiated before and maintained during carotid clamping, is feasible and safe. BACKGROUND: ClinicalTrials.gov NCT02629653.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Équipe(s) de recherche :
Troubles cognitifs dégénératifs et vasculaires
Date de dépôt :
2019-11-27T13:34:40Z