Title :

F-18-fdg-pet patterns of surgical success and failure in mesial temporal lobe epilepsy

Author(s) :

Chassoux, Francine [Auteur]
Artiges, Eric [Auteur]
Semah, Franck [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Laurent, Agathe [Auteur]
Landre, Elisabeth [Auteur]
Turak, Baris [Auteur]
Gervais, Philippe [Auteur]
Helal, Badia-Ourkia [Auteur]
Devaux, Bertrand [Auteur]

Journal title :

Neurology

Abbreviated title :

Neurology

Volume number :

88

Pages :

1045-1053

Publication date :

2017-03-14

ISSN :

0028-3878

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To search for [18 METHODS: We analyzed metabolic data with [18 RESULTS: With a mean follow-up of >6 years (range 2-14 years), 85% of patients achieved a class I outcome, including 45% in class IA. Class IA outcome ...
Show more >OBJECTIVE: To search for [18 METHODS: We analyzed metabolic data with [18 RESULTS: With a mean follow-up of >6 years (range 2-14 years), 85% of patients achieved a class I outcome, including 45% in class IA. Class IA outcome was associated with a focal anteromesial temporal hypometabolism, whereas non-IA outcome correlated with extratemporal metabolic changes that differed according to the lateralization: ipsilateral mesial frontal and perisylvian hypometabolism in right HS and contralateral fronto-insular hypometabolism and posterior white matter hypermetabolism in left HS. Suboptimal outcome presented a metabolic pattern similar to the best outcome but with a larger involvement of extratemporal areas, including the contralateral side in left HS. Failure was characterized by a mild temporal involvement sparing the hippocampus and relatively high extratemporal hypometabolism on both sides. These findings were concordant with electroclinical features reflecting the organization of the epileptogenic zone but were independent of the structural abnormalities detected on MRI. CONCLUSIONS: [18Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:34:56Z