Title :

Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study

Author(s) :

Benard-Laribiere, Anne [Auteur]
Pambrun, Elodie [Auteur]
Sutter-Dallay, Anne-Laure [Auteur]
Gautier, Sophie [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Hurault-Delarue, Caroline [Auteur]
Damase-Michel, Christine [Auteur]
Lacroix, Isabelle [Auteur]
Begaud, Bernard [Auteur]
Pariente, Antoine [Auteur]

Journal title :

British journal of clinical pharmacology

Abbreviated title :

Br J Clin Pharmacol

Publication date :

2018-04-17

ISSN :

1365-2125

English keyword(s) :

antidepressive agents
pregnancy
insurance health reimbursement
drug utilization
pharmacoepidemiology

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

We explored the patterns of antidepressant use during pregnancy. A cohort of women who started a pregnancy in 2014 was identified using data from the French reimbursement healthcare system (covering approximately 99% of ...
Show more >We explored the patterns of antidepressant use during pregnancy. A cohort of women who started a pregnancy in 2014 was identified using data from the French reimbursement healthcare system (covering approximately 99% of the population). Antidepressant usage (initiated before or during pregnancy) was assessed. Explored changes in antidepressant treatment were: associations, switches, discontinuation and resumption of antidepressants during pregnancy. The cohort included 766 508 pregnancies (755 519 women). Antidepressant use during pregnancy was 25.7 per 1000 [95% CI: 25.3-26.0]. New use concerned 3.9 per 1000 [95% CI: 3.7-4.0]; the most initiated class during pregnancy was selective serotonin reuptake inhibitors (SSRIs), while the most prescribed individual drug in second and third trimesters was amitriptyline, a tricyclic. Most changes were observed before pregnancy and during the first trimester: 63% of ongoing treatments in the year before pregnancy were discontinued before conception; 68% of treatments maintained after conception were discontinued during the first trimester; switches or antidepressant associations mostly occurred during the periconceptional period or during the first trimester. Regardless of initial antidepressant, switches to sertraline were the most frequent. Associations mainly consisted of a prescription of tri-/tetracyclic or mirtazapine/mianserin in addition to an SSRI. Discontinuation during pregnancy led to treatment resumption in 22% of pregnancies. These results suggest that pregnancy was planned or the treatment especially adapted in accordance with existing recommendations in a large proportion of women under antidepressants or in whom such treatments have been initiated after starting a pregnancy.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:35:07Z