Title :

Stereo-electroencephalography identifies n2 sleep and spindles in human hippocampus

Author(s) :

Carpentier, Nicolas [Auteur]
Cecchin, Thierry [Auteur]
Koessler, Laurent [Auteur]
Louis-Dorr, Valerie [Auteur]
Jonas, Jacques [Auteur]
Vignal, Jean-Pierre [Auteur]
Carpentier, Marc [Auteur]
Szurhaj, William [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Bourgin, Patrice [Auteur]
Maillard, Louis Georges [Auteur]

Journal title :

Clinical neurophysiology . official journal of the International Federation of Clinical Neurophysiology

Abbreviated title :

Clin. Neurophysiol.

Volume number :

128

Pages :

1696-1706

Publication date :

2017-09-01

ISSN :

1388-2457

English keyword(s) :

N2 sleep
Stereo-electroencephalography
Stereo-electroencephalogram
Hippocampus
Sleep
Depth recording
Intracerebral recording
Spindles

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

To describe the hippocampal stereo-electroencephalogram during sleep according to sleep stages (including N2 sleep) and cycles, together with the hippocampal spindles. All patients with drug-resistant focal epilepsy ...
Show more >To describe the hippocampal stereo-electroencephalogram during sleep according to sleep stages (including N2 sleep) and cycles, together with the hippocampal spindles. All patients with drug-resistant focal epilepsy undergoing intra-hippocampal implantation between August 2012 and June 2013 at Nancy University Hospital were screened. Six patients with explored hippocampus devoid of pathological features were analyzed. During one night, we identified continuous periods of successive N2, N3 and REM sleep for two full cycles. We performed a spectral analysis of the hippocampal signal for each labeled sleep period. N2, N3 and REM sleeps were individualized according to their spectral powers, for each frequency band and sleep cycle. Hippocampal spindles showed dynamic intrinsic properties, the 11.5-16Hz frequency band being mainly dominant, whereas the 9-11.5Hz frequency band heightening during the beginning and the end of the transient. For N3 and REM sleep stages, the power of the hippocampal signal was significantly decreased between the first and the second sleep cycle. Distinct N2 sleep, fast spindles and homeostatic profile are all common properties shared by hippocampus and cortex during sleep. The close functional link between hippocampus and cortex may have various sleep-related substrates.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:35:55Z