Title :

Subthalamic nucleus local field potentials recordings reveal subtle effects of promised reward during conflict resolution in parkinson''s disease

Author(s) :

Duprez, Joan [Auteur]
Houvenaghel, Jean-François [Auteur]
Dondaine, Thibaut [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Peron, Julie [Auteur]
Haegelen, Claire [Auteur]
Drapier, Sophie [Auteur]
Modolo, Julien [Auteur]
Jannin, Pierre [Auteur]
Verin, Marc [Auteur]
Sauleau, Paul [Auteur]

Journal title :

NeuroImage

Abbreviated title :

Neuroimage

Volume number :

197

Pages :

232-242

Publication date :

2019-04-30

ISSN :

1095-9572

English keyword(s) :

Neural oscillations
Local field potential
Reward
Subthalamic nucleus
Cognitive action control

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Cognitive action control depends on cortical-subcortical circuits, involving notably the subthalamic nucleus (STN), as evidenced by local field potentials recordings (LFPs) studies. The STN consistently shows an increase ...
Show more >Cognitive action control depends on cortical-subcortical circuits, involving notably the subthalamic nucleus (STN), as evidenced by local field potentials recordings (LFPs) studies. The STN consistently shows an increase in theta oscillations power during conflict resolution. Some studies have shown that cognitive action control in Parkinson's disease (PD) could be influenced by the occurrence of monetary reward. In this study, we investigated whether incentive motivation could modulate STN activity, and notably STN theta activity, during response conflict resolution. To achieve this objective, we recorded STN LFPs during a motivated Simon task in PD patients who had undergone deep brain stimulation surgery. Behavioral results revealed that promised rewards increased the difficulty in resolving conflict situations, thus replicating previous findings. Signal analyses locked on the imperative stimulus onset revealed the typical pattern of increased theta power in a conflict situation. However, this conflict-related modulation of theta power was not influenced by the size of the reward cued. We nonetheless identified a significant effect of the reward size on local functional organization (indexed by inter-trial phase clustering) of theta oscillations, with higher organization associated with high rewards while resolving conflict. When focusing on the period following the onset of the reward cue, we unveiled a stronger beta power decrease in higher reward conditions. However, these LFPs results were not correlated to behavioral results. Our study suggests that the STN is involved in how reward information can influence computations during conflict resolution. However, considering recent studies as well as the present results, we suspect that these effects are subtle.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:36:07Z