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First-in-man study of heartech� percutaneous ...
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Document type :
Article dans une revue scientifique: Article original
DOI :
10.1002/ccd.28366
PMID :
31231944
Permalink :
http://hdl.handle.net/20.500.12210/16281
Title :
First-in-man study of heartech� percutaneous left ventricular partitioning device for treatment of heart failure postmyocardial infarction
Author(s) :
Zhu, Zhengbin [Auteur]
Yu, Jiwei [Auteur]
Xu, Kai [Auteur]
Tang, Yimin [Auteur]
Fang, Yuehua [Auteur]
Gu, Jianing [Auteur]
Gu, Shengjia [Auteur]
Ding, Fenghua [Auteur]
Modine, Thomas [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Zhang, Ruiyan [Auteur]
Journal title :
Catheterization and cardiovascular interventions . official journal of the Society for Cardiac Angiography & Interventions
Abbreviated title :
Catheter Cardiovasc Interv
Publication date :
2019-06-23
ISSN :
1522-726X
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
OBJECTIVE: This first-in-man (FIM) study aimed to determine the safety and efficacy of the Heartech® left ventricular partitioning device (LVPD) in patients with chronic heart failure (HF) postmyocardial infarction. METHODS: ...
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OBJECTIVE: This first-in-man (FIM) study aimed to determine the safety and efficacy of the Heartech® left ventricular partitioning device (LVPD) in patients with chronic heart failure (HF) postmyocardial infarction. METHODS: Sixteen patients were enrolled from three cardiac intervention centers in China. All patients underwent percutaneous ventricular restoration (PVR) procedures with implantation of the Heartech® LVPD. Safety and immediate success rates were recorded. Major adverse cardiovascular and cerebrovascular events (MACCEs) including all-cause mortality, myocardial infarction, stroke, emergent or selective surgery or interventional therapy, renal failure requiring hemodialysis, and major bleeding were recorded. Efficacy features included functional status, echocardiographic characteristics, life quality characteristics including peak oxygen consumption of cardiopulmonary exercise testing (CPET), European five-dimensional health scale (EQ-5D), 6-min walk test (6MWT) at baseline and during follow-up (NCT02938637). RESULTS: The device success rate was 93.75% (15 successes in 16 patients) with 100% safety. During follow-up of 36 ± 4.5 days, no MACCEs were found. The left ventricular end-systolic volume index decreased significantly (LVESVi, 72.47 ± 22.77 mL/m2222 CONCLUSIONS: Heartech® LVPD appeared to be safe and effective for treatment of HF postmyocardial infarction.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
Collections :
  • Lille Neurosciences & Cognition (LilNCog) - U 1172
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T13:36:10Z
Université de Lille

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