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Maldi msi of lipids in experimental model ...
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Document type :
Article dans une revue scientifique: Article original
DOI :
10.1021/acs.analchem.9b02633
PMID :
31412203
Permalink :
http://hdl.handle.net/20.500.12210/16283
Title :
Maldi msi of lipids in experimental model of traumatic brain injury detects acylcarnitines as injury related markers
Author(s) :
Mallah, Khalil [Auteur]
Quanico, Jusal [Auteur]
Raffo-Romero, Antonella [Auteur]
Cardon, Tristan [Auteur]
Aboulouard, Soulaimane [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
DEVOS, DAVID [Auteur] refId
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Kobeissy, Firas [Auteur]
Zibara, Kazem [Auteur]
Salzet, Michel [Auteur] refId
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
FOURNIER, Isabelle [Auteur] refId
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192 [PRISM]
Journal title :
Analytical chemistry
Abbreviated title :
Anal. Chem.
Publication date :
2019-08-14
ISSN :
1520-6882
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Identifying new lipid markers linked to traumatic brain injury (TBI) is of major importance in characterizing their central role in the regeneration process and inflammatory response in such an injury model. In the present ...
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Identifying new lipid markers linked to traumatic brain injury (TBI) is of major importance in characterizing their central role in the regeneration process and inflammatory response in such an injury model. In the present study, an advanced lipidomics analysis using high spectral resolution matrix-assisted laser desorption/ionization-mass spectrometry imaging was performed on different brain regions in an experimental rat model of moderate controlled cortical impact (CCI) while considering different time points (1 day, 3 days, 7 days, and 10 days) assessing the acute and subacute phase after injury. Our results revealed a new family of lipids, the acylcarnitines, as TBI-lipid related markers, with maximum expression at 3 days after impact and main colocalization within resident microglia of the brain. Furthermore, our experiments highlighted the upregulation of these acylcarnitine lipids, secreted by microglia, in the ipsilateral substantia nigraShow less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
INSERM
Inserm
Université de Lille
Collections :
  • Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Submission date :
2019-11-27T13:36:13Z
Université de Lille

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