Title :

Cerebral microbleeds, vascular risk factors, and magnetic resonance imaging markers: the northern manhattan study

Author(s) :

Caunca, Michelle R. [Auteur]
Del Brutto, Victor [Auteur]
Gardener, Hannah [Auteur]
Shah, Nirav [Auteur]
Dequatre-Ponchelle, Nelly [Auteur]
Cheung, Ying Kuen [Auteur]
Elkind, Mitchel S. V. [Auteur]
Brown, Truman R. [Auteur]
Cordonnier, Charlotte [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Sacco, Ralph L. [Auteur]
Wright, Clinton B. [Auteur]

Journal title :

Journal of the American Heart Association

Abbreviated title :

J Am Heart Assoc

Volume number :

5

Publication date :

2016-09-16

ISSN :

2047-9980

English keyword(s) :

cerebral microbleed
magnetic resonance imaging
risk factor

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Cerebral microbleeds (CMBs) represent intracerebral hemorrhages due to amyloid angiopathy or exposure to modifiable risk factors. Few community-based stroke-free studies including blacks and Hispanics have been done. The ...
Show more >Cerebral microbleeds (CMBs) represent intracerebral hemorrhages due to amyloid angiopathy or exposure to modifiable risk factors. Few community-based stroke-free studies including blacks and Hispanics have been done. The Northern Manhattan Study (NOMAS) is a stroke-free, racially and ethnically diverse cohort study. Brain MRI was performed in 1290 participants, 925 of whom had available T2* gradient-recall echo data. We used multivariable logistic regression to examine the association of sociodemographics, vascular risk factors, apolipoprotein E (APOE) genotype, and brain MRI markers with CMB presence and location. The prevalence of CMBs in our cohort was 5%. Of the 46 participants with CMBs, 37% had only deep CMBs, 48% had only lobar CMBs, and 15% had CMBs in both locations. The difference in CMB distribution was not statistically significant across race/ethnic group or APOE genotype. In multivariable analyses, age (OR [95% CI]: 1.09 [1.04, 1.15]) and SBIs (2.58 [1.01, 6.59]) were positively associated with CMB presence, and diabetes medication use was negatively associated (0.25 [0.07, 0.86]). CMBs may represent the severity of vascular disease in this racially and ethnically diverse cohort. Larger studies are needed to elucidate the association between diabetes medication use and CMB presence.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:36:38Z