Title :

F-18-fdg pet hypometabolism patterns reflect clinical heterogeneity in sporadic forms of early-onset alzheimer's disease

Author(s) :

Vanhoutte, Matthieu [Auteur]
Semah, Franck [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Rollin-Sillaire, Adeline [Auteur]
Jaillard, Alice [Auteur]
Petyt, Gregory [Auteur]
Kuchcinski, Gregory [Auteur]
Maureille, Aurelien [Auteur]
Delbeuck, Xavier [Auteur]
Fahmi, Rachid [Auteur]
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Lopes, Renaud [Auteur]

Journal title :

Neurobiology of aging

Abbreviated title :

Neurobiol. Aging

Volume number :

59

Pages :

184-196

Publication date :

2017-11-01

ISSN :

0197-4580

English keyword(s) :

Atrophy regression
Cognition
Metabolism
Nonparametric permutation analysis
Sporadic early-onset Alzheimer''s disease
Positron emission tomography

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Until now, hypometabolic patterns and their correlations with neuropsychological performance have not been assessed as a function of the various presentations of sporadic early-onset Alzheimer's disease (EOAD). Here, we ...
Show more >Until now, hypometabolic patterns and their correlations with neuropsychological performance have not been assessed as a function of the various presentations of sporadic early-onset Alzheimer's disease (EOAD). Here, we processed and analyzed the patients' metabolic maps at the vertex and voxel levels by using a nonparametric, permutation method that also regressed out the effects of cortical thickness and gray matter volume, respectively. The hypometabolism patterns in several areas of the brain were significantly correlated with the clinical manifestations. These areas included the paralimbic regions for typical presentations of sporadic EOAD. For atypical presentations, the hypometabolic regions included Broca's and Wernicke's areas and the pulvinar in language forms, bilateral primary and higher processing visual regions (with right predominance) in visuospatial forms, and the bilateral prefrontal cortex in executive forms. Similar hypometabolism patterns were also observed in a correlation analysis of the 18Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:36:47Z