Title :

The role of sub-hippocampal versus hippocampal regions in bitemporal lobe epilepsies

Author(s) :

Aubert, Sandrine [Auteur]
Bonini, Francesca [Auteur]
Curot, Jonathan [Auteur]
Valton, Luc [Auteur]
Szurhaj, William [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Derambure, Philippe [Auteur]
Médicaments et molécules pour agir sur les Systèmes Vivants - U 1177 [M2SV]
Médicaments et molécules pour agir sur les Systèmes Vivants - U 1177 [M2SV]
Rheims, Sylvain [Auteur]
Ryvlin, Philippe [Auteur]
Wendling, Fabrice [Auteur]
Mcgonigal, Aileen [Auteur]
Trebuchon, Agnes [Auteur]
Bartolomei, Fabrice [Auteur]

Journal title :

Clinical neurophysiology . official journal of the International Federation of Clinical Neurophysiology

Abbreviated title :

Clin. Neurophysiol.

Volume number :

127

Pages :

2992-2999

Publication date :

2016-09-01

ISSN :

1388-2457

English keyword(s) :

Bilateral temporal epilepsy
Surgery
Epileptogenicity Index
Entorhinal cortex
SEEG

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: We aimed at better delineating the functional anatomical organization of bitemporal lobe epilepsy. METHODS: We studied the epileptogenic zone (EZ) by quantifying the epileptogenicity of brain structures explored ...
Show more >OBJECTIVE: We aimed at better delineating the functional anatomical organization of bitemporal lobe epilepsy. METHODS: We studied the epileptogenic zone (EZ) by quantifying the epileptogenicity of brain structures explored by depth electrodes in patients investigated by stereoelectroencephalography (SEEG). We compared 15 patients with bilateral mesial temporal lobe epilepsy (BTLE) and 15 patients with unilateral mesial temporal lobe epilepsy (UTLE). This quantification was performed using the 'Epileptogenicity Index' (EI). RESULTS: Age at epilepsy onset, and epilepsy duration, were not statistically different in both groups. UTLE patients more frequently displayed maximal epileptogenicity in hippocampal structures, whereas BTLE patients had maximal values in subhippocampal areas (entorhinal cortex, temporal pole, parahippocampal cortex). CONCLUSIONS: Our results suggest different organization of the EZ in the two groups. CONCLUSIONS: BTLE was associated with more involvement of subhippocampal regions, a result in agreement with known anatomical connections between the two temporal lobes.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Médicaments et Molécules pour agir sur les Systèmes Vivants (M2SV) - U1177

Submission date :

2019-11-27T13:37:26Z