Title :

Role of cortical microbleeds in cognitive impairment: In vivo behavioral and imaging characterization of a novel murine model

Author(s) :

Bergeron, Sandrine [Auteur]
Troubles cognitifs vasculaires et dégénératifs
Chen, Yaohua [Auteur]
Troubles cognitifs vasculaires et dégénératifs
Auger, Florent [Auteur]
Imagerie fonctionnelle et exploration du vivant = Lille in vivo imaging and Functional Exploration - PLBS [LiiFE]
Deguil, Julie [Auteur]
Troubles cognitifs vasculaires et dégénératifs
Durieux, Nicolas [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Skrobala, Emilie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Barus, Romain [Auteur]
Troubles cognitifs vasculaires et dégénératifs
Potey, Camille [Auteur]
Troubles cognitifs vasculaires et dégénératifs
Cordonnier, Charlotte [Auteur]
Troubles cognitifs vasculaires et dégénératifs
Pasquier, Florence [Auteur]
Troubles cognitifs vasculaires et dégénératifs
Ravasi, Laura [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Bordet, Regis [Auteur]
Troubles cognitifs vasculaires et dégénératifs
GAUTIER, Sophie [Auteur]
Troubles cognitifs vasculaires et dégénératifs

Journal title :

Journal of Cerebral Blood Flow and Metabolism

Abbreviated title :

J. Cereb. Blood Flow Metab.

Volume number :

39

Pages :

1015-1025

Publisher :

SAGE Journals

Publication date :

2018-01-01

ISSN :

1559-7016

English keyword(s) :

preclinical model
rodents
pharmacological modulation
Cognitive impairment
microbleed

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Cerebral microbleeds (CMBs) could contribute to cognitive impairment in the general population and in patients with dementia. We designed a study to (i) develop a murine model of CMBs, (ii) assess whether CMBs affect ...
Show more >Cerebral microbleeds (CMBs) could contribute to cognitive impairment in the general population and in patients with dementia. We designed a study to (i) develop a murine model of CMBs, (ii) assess whether CMBs affect cognition in this model and (iii) assess whether this model is sensitive to pharmacological modulation. Male C57Bl6/J mice were stereotactically administered collagenase to induce cortical lesion analysed by MRI at 24 h. CMB-mice were assessed at six weeks post-lesion for cognitive performances (Barnes maze and Touchscreen automated paired-associated learning (PAL) task) and for cerebral metabolism (in vivo PET/CT with fluorodeoxyglucose (FDG)). CMB-model sensitivity to pharmacological modulation was assessed by administering atorvastatin (5 mg/kg/day) over the follow-up period. CMB mice were compared to naïve littermates. Collagenase at 0.8 µU/µl appeared suitable to induce reproducible and reliable CMBs. At six weeks, a decline in learning, spatial and visuospatial memory was significantly observed in CMB-mice. Brain metabolism was impaired in all cortex, striatum and the ipsilateral dentate gyrus. A significant improvement in cognition performances was depicted under atorvastatin. In this novel murine model of CMBs, we validated that CMBs lowered cognitive performances and affected regional metabolism. We also proved that this CMB-model is sensitive to pharmacological modulation.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T13:38:27Z
2025-04-09T10:12:03Z