Title :

Is associated with white matter hyperintensities (n = 11,226)

Author(s) :

Traylor, Matthew [Auteur]
Tozer, Daniel J. [Auteur]
Croall, Iain D. [Auteur]
Lisiecka Ford, Danuta M. [Auteur]
Olorunda, Abiodun Olubunmi [Auteur]
Boncoraglio, Giorgio B. [Auteur]
Dichgans, Martin [Auteur]
Lemmens, Robin [Auteur]
Rosand, Jonathan [Auteur]
Rost, Natalia S. [Auteur]
Rothwell, Peter M. [Auteur]
Sudlow, Cathie L. M. [Auteur]
Thijs, Vincent N. S. [Auteur]
Rutten-Jacobs, Loes [Auteur]
Markus, Hugh S. [Auteur]

Journal title :

Neurology

Abbreviated title :

Neurology

Publication date :

2019-01-18

ISSN :

1526-632X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

To identify novel genetic associations with white matter hyperintensities (WMH). We performed a genome-wide association meta-analysis of WMH volumes in 11,226 individuals, including 8,429 population-based individuals from ...
Show more >To identify novel genetic associations with white matter hyperintensities (WMH). We performed a genome-wide association meta-analysis of WMH volumes in 11,226 individuals, including 8,429 population-based individuals from UK Biobank and 2,797 stroke patients. Replication of novel loci was performed in an independent dataset of 1,202 individuals. In all studies, WMH were quantified using validated automated or semi-automated methods. Imputation was to either the Haplotype Reference Consortium or 1,000 Genomes Phase 3 panels. We identified a locus at genome-wide significance in an intron of PLEKHG1p-8p-9ppp-11p-12 Genetic variation in PLEKHG1Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:28:42Z