Sex differences in the occurrence of major ...
Document type :
Article dans une revue scientifique: Article original
DOI :
PMID :
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Title :
Sex differences in the occurrence of major clinical events in elderly people with type 2 diabetes mellitus followed up in the general practice
Author(s) :
Al-Salameh, Abdallah [Auteur]
Bucher, Sophie [Auteur]
Bauduceau, Bernard [Auteur]
Benattar-Zibi, Linda [Auteur]
Berrut, Gilles [Auteur]
Bertin, Philippe [Auteur]
Corruble, Emmanuelle [Auteur]
Danchin, Nicolas [Auteur]
Derumeaux, Genevieve [Auteur]
Doucet, Jean [Auteur]
Falissard, Bruno [Auteur]
Forette, Françoise [Auteur]
Hanon, Olivier [Auteur]
Ourabah, Rissane [Auteur]
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Pinget, Michel [Auteur]
Becquemont, Laurent [Auteur]
Ringa, Virginie [Auteur]
Bucher, Sophie [Auteur]
Bauduceau, Bernard [Auteur]
Benattar-Zibi, Linda [Auteur]
Berrut, Gilles [Auteur]
Bertin, Philippe [Auteur]
Corruble, Emmanuelle [Auteur]
Danchin, Nicolas [Auteur]
Derumeaux, Genevieve [Auteur]
Doucet, Jean [Auteur]
Falissard, Bruno [Auteur]
Forette, Françoise [Auteur]
Hanon, Olivier [Auteur]
Ourabah, Rissane [Auteur]
Pasquier, Florence [Auteur]

Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Pinget, Michel [Auteur]
Becquemont, Laurent [Auteur]
Ringa, Virginie [Auteur]
Journal title :
Experimental and clinical endocrinology & diabetes . official journal, German Society of Endocrinology [and] German Diabetes Association
Abbreviated title :
Exp. Clin. Endocrinol. Diabetes
Publication date :
2018-08-22
ISSN :
1439-3646
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
OBJECTIVE: The main aim of the present work was to assess if sex influences the occurrence of major clinical events in elderly people with type 2 diabetes followed up in the primary care.
METHODS: 983 subjects aged ≥65years ...
Show more >OBJECTIVE: The main aim of the present work was to assess if sex influences the occurrence of major clinical events in elderly people with type 2 diabetes followed up in the primary care. METHODS: 983 subjects aged ≥65years with type 2 diabetes were included by 213 general practitioners and followed up prospectively for three years. Major clinical events were recorded every six month. The first endpoint was a composite of all-cause death and major vascular events (acute coronary syndrome, non-fatal stroke or transient ischemic attack, or revascularization for peripheral artery disease). The second endpoint was all-cause hospitalization. The occurrence of each endpoint was analyzed in order to estimate the role of sex and determine other predictors of major clinical events. RESULTS: At baseline, women were older than men but they had a lower prevalence of coexisting diseases (cardiovascular disease and cancer) and equivalent diabetes control (Glycated hemoglobin A1C: 6.9%±0.9 vs. 7.0%±1.1). Over the follow-up period, women were at lower risk to develop the composite endpoint (HR 0.60, 95% CI 0.40-0.91, p=0.016) and the hospitalization endpoint (OR 0.71, 95% CI 0.52-0.96, p=0.029). Coexisting diseases, functional ability and concomitant medications emerged as significant predictors of both endpoints. CONCLUSIONS: Elderly women with well-controlled type 2 diabetes were less likely to experience major clinical events than their male counterparts. More studies are needed to determine the reasons for the higher hospitalization rate in men.Show less >
Show more >OBJECTIVE: The main aim of the present work was to assess if sex influences the occurrence of major clinical events in elderly people with type 2 diabetes followed up in the primary care. METHODS: 983 subjects aged ≥65years with type 2 diabetes were included by 213 general practitioners and followed up prospectively for three years. Major clinical events were recorded every six month. The first endpoint was a composite of all-cause death and major vascular events (acute coronary syndrome, non-fatal stroke or transient ischemic attack, or revascularization for peripheral artery disease). The second endpoint was all-cause hospitalization. The occurrence of each endpoint was analyzed in order to estimate the role of sex and determine other predictors of major clinical events. RESULTS: At baseline, women were older than men but they had a lower prevalence of coexisting diseases (cardiovascular disease and cancer) and equivalent diabetes control (Glycated hemoglobin A1C: 6.9%±0.9 vs. 7.0%±1.1). Over the follow-up period, women were at lower risk to develop the composite endpoint (HR 0.60, 95% CI 0.40-0.91, p=0.016) and the hospitalization endpoint (OR 0.71, 95% CI 0.52-0.96, p=0.029). Coexisting diseases, functional ability and concomitant medications emerged as significant predictors of both endpoints. CONCLUSIONS: Elderly women with well-controlled type 2 diabetes were less likely to experience major clinical events than their male counterparts. More studies are needed to determine the reasons for the higher hospitalization rate in men.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
CHU Lille
CNRS
Inserm
Université de Lille
CNRS
Inserm
Université de Lille
Collections :
Research team(s) :
Troubles cognitifs dégénératifs et vasculaires
Submission date :
2019-11-27T14:29:27Z