Title :

Functional impairments for outcomes in a randomized trial of unruptured brain avms

Author(s) :

Mohr, J. P. [Auteur]
Overbey, Jessica R. [Auteur]
Von Kummer, Ruediger [Auteur]
Stefani, Marco A. [Auteur]
Libman, Richard [Auteur]
Stapf, Christian [Auteur]
Parides, Michael K. [Auteur]
Pile-Spellman, John [Auteur]
Moquete, Ellen [Auteur]
Moy, Claudia S. [Auteur]
Vicaut, Eric [Auteur]
Moskowitz, Alan J. [Auteur]
Harkness, Kirsty [Auteur]
Cordonnier, Charlotte [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 [TCDV]
Biondi, Alessandra [Auteur]
Houdart, Emmanuel [Auteur]
Berkefeld, Joachim [Auteur]
Klijn, Catharina J. M. [Auteur]
Barreau, Xavier [Auteur]
Kim, Helen [Auteur]
Hartmann, Andreas [Auteur]

Journal title :

Neurology

Abbreviated title :

Neurology

Volume number :

89

Pages :

1499-1506

Publication date :

2017-10-03

ISSN :

0028-3878

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

OBJECTIVE: To investigate the effects of medical vs interventional management on functional outcome in A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA). METHODS: We used the initial results of a ...
Show more >OBJECTIVE: To investigate the effects of medical vs interventional management on functional outcome in A Randomized Trial of Unruptured Brain Arteriovenous Malformations (ARUBA). METHODS: We used the initial results of a nonblinded, randomized, controlled, parallel-group trial involving adults ≥18 years of age with an unruptured brain arteriovenous malformation (AVM) to compare the effects of medical management (MM) with or without interventional therapy (IT) on functional impairment, defined by a primary outcome of death or symptomatic stroke causing modified Rankin Scale (mRS) score ≥2. ARUBA closed recruitment on April 15, 2013. RESULTS: After a median of 33.3 months of follow-up (interquartile range 16.3-49.8 months), of the 223 enrolled in the trial, those in the MM arm were less likely to experience primary outcomes with an mRS score ≥2 than those who underwent IT. The results applied for both those as randomized (MM n = 109 vs IT n = 114) (hazard ratio [HR] 0.25, 95% confidence interval [CI] 0.11-0.57, ppp CONCLUSIONS: Death or stroke with functional impairment in ARUBA after a median follow-up of 33 months was significantly lower for those in the MM arm both as randomized and as treated compared with those with IT. Functional severity of outcomes was lower in the MM arm, regardless of Spetzler-Martin grades. NCT00389181. METHODS: This study provides Class II evidence that for adults with unruptured brain AVMs, interventional management compared to MM increases the risk of disability and death over ≈3 years.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:30:03Z