Title :

Added value of (18)f-florbetaben amyloid pet in the diagnostic workup of most complex patients with dementia in france: a naturalistic study

Author(s) :

Ceccaldi, Mathieu [Auteur]
Jonveaux, Therese [Auteur]
Verger, Antoine [Auteur]
Krolak-Salmon, Pierre [Auteur]
Houzard, Claire [Auteur]
Godefroy, Olivier [Auteur]
Shields, Trevor [Auteur]
Perrotin, Audrey [Auteur]
Gismondi, Rossella [Auteur]
Bullich, Santiago [Auteur]
Jovalekic, Aleksandar [Auteur]
Raffa, Nicola [Auteur]
Pasquier, Florence [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Semah, Franck [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Dubois, Bruno [Auteur]
Habert, Marie-Odile [Auteur]
Wallon, David [Auteur]
Chastan, Mathieu [Auteur]
Payoux, Pierre [Auteur]
Stephens, Andrew [Auteur]
Guedj, Eric [Auteur]

Journal title :

Alzheimer's & dementia . the journal of the Alzheimer's Association

Abbreviated title :

Alzheimers Dement

Publication date :

2017-11-04

ISSN :

1552-5279

English keyword(s) :

Amyloid imaging
Florbetaben
Alzheimer''s disease
Clinical practice
Diagnosis
Patient management

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Although some studies have previously addressed the clinical impact of amyloid positron emission tomography (PET), none has specifically addressed its selective and hierarchical implementation in relation to cerebrospinal ...
Show more >Although some studies have previously addressed the clinical impact of amyloid positron emission tomography (PET), none has specifically addressed its selective and hierarchical implementation in relation to cerebrospinal fluid analysis in a naturalistic setting. This multicenter study was performed at French tertiary memory clinics in patients presenting with most complex clinical situations (i.e., early-onset, atypical clinical profiles, suspected mixed etiological conditions, unexpected rate of progression), for whom cerebrospinal fluid analysis was indicated but either not feasible or considered as noncontributory (ClinicalTrials.gov: NCT02681172). Two hundred five patients were enrolled with evaluable florbetaben PET scans; 64.4% of scans were amyloid positive. PET results led to changed diagnosis and improved confidence in 66.8% and 81.5% of patients, respectively, and altered management in 80.0% of cases. High-level improvement of diagnostic certainty and management is provided by selective and hierarchical implementation of florbetaben PET into current standard practices for the most complex dementia cases.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:30:04Z