Title :

Sex differences and functional outcome after intravenous thrombolysis

Author(s) :

Spaander, Fianne H. [Auteur]
Zinkstok, Sanne M. [Auteur]
Baharoglu, M. Irem [Auteur]
Gensicke, Henrik [Auteur]
Polymeris, Alexandros A. [Auteur]
Traenka, Christopher [Auteur]
Hametner, Christian [Auteur]
Ringleb, Peter Arthur [Auteur]
Curtze, Sami [Auteur]
Martinez-Majander, Nicolas [Auteur]
Aarnio, Karoliina [Auteur]
Nolte, Christian H. [Auteur]
Scheitz, Jan F. [Auteur]
LEYS, Didier [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Hochart, Anais [Auteur]
Padjen, Visnja [Auteur]
Kagi, Georg [Auteur]
Pezzini, Alessandro [Auteur]
Michel, Patrik [Auteur]
Bill, Olivier [Auteur]
Zini, Andrea [Auteur]
Engelter, Stefan T. [Auteur]
Nederkoorn, Paul J. [Auteur]

Journal title :

Stroke

Abbreviated title :

Stroke

Volume number :

48

Pages :

699-703

Publication date :

2017-03-01

ISSN :

0039-2499

English keyword(s) :

age distribution
female
thrombolytic therapy
registries
stroke

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Women have a worse outcome after stroke compared with men, although in intravenous thrombolysis (IVT)-treated patients, women seem to benefit more. Besides sex differences, age has also a possible effect on functional ...
Show more >Women have a worse outcome after stroke compared with men, although in intravenous thrombolysis (IVT)-treated patients, women seem to benefit more. Besides sex differences, age has also a possible effect on functional outcome. The interaction of sex on the functional outcome in IVT-treated patients in relation to age remains complex. The purpose of this study was to compare outcome after IVT between women and men with regard to age in a large multicenter European cohort reflecting daily clinical practice of acute stroke care. Data were obtained from IVT registries of 12 European tertiary hospitals. The primary outcome was poor functional outcome, defined as a modified Rankin scale score of 3 to 6 at 3 months. We stratified outcome by age in decades. Safety measures were symptomatic intracranial hemorrhage and mortality at 3 months. In this cohort, 9495 patients were treated with IVT, and 4170 (43.9%) were women with a mean age of 71.9 years. After adjustments for baseline differences, female sex remained associated with poor functional outcome (odds ratio, 1.15; 95% confidence interval, 1.02-1.31). There was no association between sex and functional outcome when data were stratified by age. Symptomatic intracranial hemorrhage rate was similar in both sexes (adjusted odds ratio, 0.93; 95% confidence interval, 0.73-1.19), whereas mortality was lower among women (adjusted odds ratio, 0.83; 95% confidence interval, 0.70-0.99). In this large cohort of IVT-treated patients, women more often had poor functional outcome compared with men. This difference was not dependent on age.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:30:23Z