Title :

Predictors, incidence, and outcomes of patients undergoing transfemoral transcatheter aortic valve implantation complicated by stroke

Author(s) :

Vlastra, Wieneke [Auteur]
Jimenez-Quevedo, Pilar [Auteur]
Tchetche, Didier [Auteur]
Chandrasekhar, Jaya [Auteur]
De Brito, Fabio Sandoli [Auteur]
Barbanti, Marco [Auteur]
Kornowski, Ran [Auteur]
Latib, Azeem [Auteur]
D''''onofrio, Augusto [Auteur]
Ribichini, Flavio [Auteur]
Baan, Jan [Auteur]
Tijssen, Jan G P. [Auteur]
De La Torre Hernandez, Jose M. [Auteur]
Dumonteil, Nicolas [Auteur]
Sarmento-Leite, Rogerio [Auteur]
Sartori, Samantha [Auteur]
Rosato, S. [Auteur]
Tarantini, Giuseppe [Auteur]
Lunardi, Mattia [Auteur]
Orvin, Katia [Auteur]
Pagnesi, Matteo [Auteur]
Hernandez-Antolin, Rosana [Auteur]
Modine, Thomas [Auteur]
Troubles cognitifs dégénératifs et vasculaires - U1171
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Troubles cognitifs dégénératifs et vasculaires - U 1171 [TCDV]
Dangas, George [Auteur]
Mehran, Roxana [Auteur]
Piek, Jan J. [Auteur]
Delewi, Ronak [Auteur]

Journal title :

Circulation. Cardiovascular interventions

Abbreviated title :

Circ Cardiovasc Interv

Volume number :

12

Pages :

e007546

Publication date :

2019-03-01

ISSN :

1941-7632

English keyword(s) :

incidence
stroke
transcatheter aortic valve replacement
humans
follow-up studies

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

BACKGROUND: Stroke remains one of the most devastating complications of transcatheter aortic valve implantation (TAVI). The aim of this study was to identify the incidence, timing, temporal trends, and predictors of stroke ...
Show more >BACKGROUND: Stroke remains one of the most devastating complications of transcatheter aortic valve implantation (TAVI). The aim of this study was to identify the incidence, timing, temporal trends, and predictors of stroke after TAVI and evaluate the outcomes of patients with stroke. RESULTS: The CENTER-Collaboration is an international collaboration consisting of 3 national registries and 7 local registries or prospective clinical trials, selected through a systematic review. Accordingly, a total of 10 982 patients undergoing transfemoral TAVI between 2007 and 2018 were included in the current patient-level pooled analyses. A total of 261 patients (2.4%) experienced stroke during the first month after TAVI. The median time between TAVI and stroke was 1 day (interquartile range, 0-6 days). The stroke rate was comparable in procedures performed in the early years of TAVI (2007-2012) to those in the more recent years of TAVI (2013-2018; both 2.4%; P=1.0). Independent predictors of stroke at 30 days were a history of cerebrovascular events (odds ratio, 2.2; 95% CI, 1.4-3.6; P=0.0012) and a glomerular filtration rate of <30 mL/min per 1.73 m2 CONCLUSIONS: In this large, global, patient-level analysis, the incidence of stroke after transfemoral TAVI was 2.4%. Prior cerebrovascular events and a low glomerular filtration rate independently predicted the occurrence of stroke after TAVI. The occurrence of stroke after TAVI was associated with a strikingly 6-fold increase of 30-day mortality; additionally, there was a 5-fold higher rate of new-onset atrial fibrillation in patients with stroke. BACKGROUND: URL: https://www.clinicaltrials.gov . Unique identifier: NCT03588247.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Université de Lille

Collections :

• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2019-11-27T14:31:14Z